期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 196, 期 3, 页码 681-689出版社
WILEY
DOI: 10.1111/bjh.17874
关键词
Epstein-Barr virus status; Burkitt lymphoma; age; mutations
类别
资金
- KinderKrebs Initiative Buchholz, Holm-Seppensen (KKI)
- DFG Research Infrastructure NGS_CC as part of the Next Generation Sequencing Competence Network [407495230, 423957469]
- Projekt DEAL
Sporadic Burkitt lymphoma shows molecular heterogeneity across different age groups, with mutations commonly seen in pediatric BL such as ID3, TCF3, and CCND3 decreasing in adult patients. EBV-positive lymphomas are more frequent in adult patients and exhibit distinct pathogenic features compared to EBV-negative tumors.
Sporadic Burkitt lymphoma (BL) is the most frequent tumour of children and adolescents but a rare subtype of lymphomas in adults. To date most molecular data have been obtained from lymphomas arising in the young. Recently, Epstein-Barr virus (EBV) positive and negative BL in young patients was shown to differ in molecular features. In the present study, we present a large age-overarching cohort of sporadic BL (n = 162) analysed by immunohistochemistry, translocations of MYC proto-oncogene, basic helix-loop-helix transcription factor (MYC), B-cell leukaemia/lymphoma 2 (BCL2) and B-cell leukaemia/lymphoma 6 (BCL6) and by targeted sequencing. We illustrate an age-associated inter-tumoral molecular heterogeneity in this disease. Mutations affecting inhibitor of DNA binding 3, HLH protein (ID3), transcription factor 3 (TCF3) and cyclin D3 (CCND3), which are highly recurrent in paediatric BL, and expression of sex determining region Y-box transcription factor 11 (SOX11) declined with patient age at diagnosis (P = 0 center dot 0204 and P = 0 center dot 0197 respectively). In contrast, EBV was more frequently detected in adult patients (P = 0 center dot 0262). Irrespective of age, EBV-positive sporadic BL showed significantly less frequent mutations in ID3/TCF3/CCND3 (P = 0 center dot 0088) but more often mutations of G protein subunit alpha 13 (GNA13; P = 0 center dot 0368) and forkhead box O1 (FOXO1; P = 0 center dot 0044) compared to EBV-negative tumours. Our findings suggest that among sporadic BL an EBV-positive subgroup of lymphomas increases with patient age that shows distinct pathogenic features reminiscent of EBV-positive endemic BL.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据