期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 196, 期 3, 页码 706-710出版社
WILEY
DOI: 10.1111/bjh.17966
关键词
acute lymphoblastic leukaemia; minimal residual disease; prognostic factors; PCR; IG; TR rearrangements
类别
The study aimed to evaluate the significance of low-level minimal residual disease (MRD) during early consolidation treatment in adult BCR-ABL1-negative acute lymphoblastic leukaemia. MRDnq before the first and second consolidation blocks had a comparable negative effect on survival as MRDq. No CNS infiltration and MRD at week 11 were independent prognostic factors for survival.
The aim of the present study was to evaluate the significance of low-level minimal/measurable residual disease (MRD) during early consolidation treatment in adult BCR-ABL1-negative acute lymphoblastic leukaemia. The MRD load was monitored by immunoglobulin/T-cell receptor rearrangements and assessed as negative [complete MRD response (CMR)], positive non-quantifiable (MRDnq) and positive quantifiable (MRDq). MRDnq before the first and second consolidation blocks had a comparable negative effect on survival as MRDq. The 5-year overall survival for CMR, MRDnq and MRDq at week 11 was 74 center dot 0%, 42 center dot 3% and 35 center dot 0% respectively. No central nervous system infiltration and MRD at week 11 were independent prognostic factors for survival on multivariate analysis (hazard ratios 0 center dot 32 and 2 center dot 25).
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