4.7 Article

Metabolic stress induces GD2+ cancer stem cell-like phenotype in triple-negative breast cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Multidisciplinary Sciences

Ganglioside GD2: a novel therapeutic target in triple-negative breast cancer

Claire Shao et al.

Summary: TNBC is a heterogeneous disease characterized by lack of hormone receptor expression, with high recurrence and distant metastasis rates. Targeting breast cancer stem-like cells is an effective strategy for preventing metastatic spread and enhancing sensitivity to chemotherapy.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2022)

Article Medicine, Research & Experimental

Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer

Deanna N. Edwards et al.

Summary: Research shows an inverse correlation between glutamine metabolic genes and markers of T cell-mediated cytotoxicity in basal-like breast cancer patients, with increased glutamine metabolism associated with poor survival. Targeting glutamine metabolism selectively in tumors may be a promising therapeutic strategy for improving antitumor immune responses.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Oncology

Anti-GD2 antibody dinutuximab inhibits triple-negative breast tumor growth by targeting GD2+ breast cancer stem-like cells

Stanley Ly et al.

Summary: GD2 is expressed in around 60% of primary TNBC tumors at variable levels and is associated with worse overall survival of patients with TNBC. Treatment with dinutuximab significantly decreased adhesion and migration of TNBC cells, inhibited mTOR signaling, and reduced tumor growth in both cell-line xenografts and PDX models. Our data provide proof-of-concept for the critical role of GD2 in BCSCs and demonstrate the potential of dinutuximab as a novel therapeutic approach for TNBC.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Oncology

Metabolic Reprogramming in Triple-Negative Breast Cancer

Sun Xiangyu et al.

FRONTIERS IN ONCOLOGY (2020)

Review Oncology

Metabolic Adaptations in Cancer Stem Cells

Umesh Prasad Yadav et al.

FRONTIERS IN ONCOLOGY (2020)

Article Multidisciplinary Sciences

Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis

Nandini Verma et al.

SCIENCE ADVANCES (2020)

Review Biochemistry & Molecular Biology

Role of GPX4 in ferroptosis and its pharmacological implication

Tobias M. Seibt et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Review Oncology

Lipid metabolism in cancer cells under metabolic stress

Rimsha Munir et al.

BRITISH JOURNAL OF CANCER (2019)

Article Multidisciplinary Sciences

UGCG influences glutamine metabolism of breast cancer cells

Nina Schoemel et al.

SCIENTIFIC REPORTS (2019)

Article Biochemistry & Molecular Biology

Combined sialic acid and histone deacetylase (HDAC) inhibitor treatment up-regulates the neuroblastoma antigen GD2

Renske J. E. van den Bijgaart et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Review Biochemistry & Molecular Biology

Cancer stem cells (CSCs): metabolic strategies for their identification and eradication

Ernestina M. de Francesco et al.

BIOCHEMICAL JOURNAL (2018)

Article Biochemistry & Molecular Biology

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models

Michael L. Schulte et al.

NATURE MEDICINE (2018)

Article Pharmacology & Pharmacy

Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets

Angelika Broer et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Oncology

Pushing the Limits of Cancer Therapy: The Nutrient Game

Daniele Lettieri-Barbato et al.

FRONTIERS IN ONCOLOGY (2018)

Review Oncology

Hallmarks of cancer stem cell metabolism

Patricia Sancho et al.

BRITISH JOURNAL OF CANCER (2016)

Review Oncology

From Krebs to clinic: glutamine metabolism to cancer therapy

Brian J. Altman et al.

NATURE REVIEWS CANCER (2016)

Article Biochemistry & Molecular Biology

Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway

P-P Liu et al.

CELL DEATH AND DIFFERENTIATION (2014)

Article Oncology

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

Matt I. Gross et al.

MOLECULAR CANCER THERAPEUTICS (2014)

Article Medicine, Research & Experimental

Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells

M. Cecilia Caino et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Medicine, Research & Experimental

Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis

Venkata Lokesh Battula et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Oncology

Glucose deprivation-induced metabolic oxidative stress and cancer therapy

Andrean L. Simons et al.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2009)