4.7 Article

Toward platelet transcriptomics in cancer diagnosis, prognosis and therapy

期刊

BRITISH JOURNAL OF CANCER
卷 126, 期 3, 页码 316-322

出版社

SPRINGERNATURE
DOI: 10.1038/s41416-021-01627-z

关键词

-

类别

资金

  1. US National Institutes of Health [1K08HG01006101A1, 3UL1TR001085-04S1]
  2. UK National Institute for Health Research

向作者/读者索取更多资源

Advancements in next-generation techniques like RNA-sequencing have allowed for research into the transcriptome of anucleate blood platelets, revealing a rich platelet transcriptomic signature altered in response to disease. These platelet signatures capture information from parent cells and reflect influences of tumors, stroma, and vasculature. Despite potential for cancer diagnosis and prognosis, clinical translation of platelet transcriptomics remains limited.
Widespread adoption of next-generation techniques such as RNA-sequencing (RNA-seq) has enabled research examining the transcriptome of anucleate blood platelets in health and disease, thus revealing a rich platelet transcriptomic signature that is reprogrammed in response to disease. Platelet signatures not only capture information from parent megakaryocytes and progenitor hematopoietic stem cells but also the bone marrow microenvironment, and underlying disease states. In cancer, the substantive body of research in patients with solid tumours has identified distinct signatures in 'tumour-educated platelets', reflecting influences of the tumour, stroma and vasculature on splicing, sequestration of tumour-derived RNAs, and potentially cytokine and microvesicle influences on megakaryocytes. More recently, platelet RNA expression has emerged as a highly sensitive approach to profiling chronic progressive haematologic malignancies, where the combination of large data cohorts and machine-learning algorithms enables precise feature selection and potential prognostication. Despite these advances, however, our ability to translate platelet transcriptomics toward clinical diagnostic and prognostic efforts remains limited. In this Perspective, we present a few actionable steps for our basic, translational and clinical research communities in advancing the utility of the platelet transcriptome as a highly sensitive biomarker in cancer and collectively enable efforts toward clinical translation and patient benefit.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据