4.7 Review

Faecal immunochemical test for patients with 'high-risk' bowel symptoms: a large prospective cohort study and updated literature review

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Summary: Optimizing colonoscopy resources in primary health care is challenging. This study assessed the impact of different FIT positivity thresholds on CRC detection in primary care, suggesting that a tailored FIT threshold should be based on colonoscopy capacity and CRC prevalence in specific populations.

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Summary: This study aimed to audit the use of FIT in symptomatic patients and found that FIT had a sensitivity of 87.5% and a specificity of 52.6% for CRC. The study also suggested that patients with anaemia were more likely to have fHb levels greater than or equal to 10 mu g/g.

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Faecal immunochemical test is superior to symptoms in predicting pathology in patients with suspected colorectal cancer symptoms referred on a 2WW pathway: a diagnostic accuracy study

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Summary: The study indicated that the sensitivity of FIT is maximized at the lowest cut-off of 2 mu g/g, reaching 97.0%. A negative FIT result at this cut-off can effectively rule out CRC, while a positive FIT result is better than symptoms for selecting patients for urgent investigations.
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Diagnostic performance of a faecal immunochemical test for patients with low-risk symptoms of colorectal cancer in primary care: an evaluation in the South West of England

Sarah E. R. Bailey et al.

Summary: This study found that the faecal immunochemical test (FIT) performed well in triaging patients with low-risk symptoms of colorectal cancer, with a positive predictive value of 7.0%, a negative predictive value of 99.8%, a sensitivity of 84.3%, and a specificity of 85.0%.

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Summary: The study aimed to assess the diagnostic accuracy of FIT in patients suspected of CRC, revealing that FIT can effectively identify CRC and significant premalignant polyps, as well as other organic enteric diseases, potentially facilitating more personalized risk assessment for colorectal cancer.

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Choice of faecal immunochemical test matters: comparison of OC-Sensor and HM-JACKarc, in the assessment of patients at high risk of colorectal cancer

Caroline J. Chapman et al.

Summary: The study found large variations in f-Hb when different FIT devices were used, but smaller variation when the same FIT device was used. This suggests that analyzer-specific f-Hb cut-offs should be applied with regard to clinical decision making, especially at lower f-Hb levels.

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Systematic review with meta-analysis of over 90 000 patients. Does fast-track review diagnose colorectal cancer earlier?

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The faecal immunochemical test in low risk patients with suspected bowel cancer

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Evaluation of sample stability for a quantitative faecal immunochemical test and comparison of two sample collection approaches

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Risk stratification of symptomatic patients suspected of colorectal cancer using faecal and urinary markers

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Diagnostic accuracy of faecal biomarkers in detecting colorectal cancer and adenoma in symptomatic patients

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Faecal immunochemical tests for the diagnosis of symptomatic colorectal cancer in primary care: the benefit of more than one sample

Cecilia Hogberg et al.

SCANDINAVIAN JOURNAL OF PRIMARY HEALTH CARE (2017)

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Use of a faecal immunochemical test for haemoglobin can aid in the investigation of patients with lower abdominal symptoms

Ian M. Godber et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2016)

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STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration

Jeremie F. Cohen et al.

BMJ OPEN (2016)

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P. Vulliamy et al.

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Accuracy of Fecal Immunochemical Tests for Colorectal Cancer Systematic Review and Meta-analysis

Jeffrey K. Lee et al.

ANNALS OF INTERNAL MEDICINE (2014)

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Faecal haemoglobin concentrations vary with sex and age, but data are not transferable across geography for colorectal cancer screening

Callum G. Fraser et al.

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Impact of the United Kingdom National Bowel Cancer Awareness Campaign on Colorectal Services

R. Pande et al.

DISEASES OF THE COLON & RECTUM (2014)