期刊
BRITISH JOURNAL OF CANCER
卷 126, 期 5, 页码 815-821出版社
SPRINGERNATURE
DOI: 10.1038/s41416-021-01645-x
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资金
- National Natural Science Foundation of China [81903382, 91846303]
- Natural Science Foundation of Jiangsu Province [BK20190652]
- National Key R&D Program of China [2016YFC0900500, 2016YFC0900501, 2016YFC0900504]
- China Postdoctoral Science Foundation [2019M651900]
- Kadoorie Charitable Foundation in Hong Kong
- UK Wellcome Trust [212946/Z/18/Z, 202922/Z/16/Z, 104085/Z/14/Z, 088158/Z/09/Z]
- Chinese Ministry of Science and Technology [2011BAI09B01]
The study found that adhering to a healthy lifestyle can significantly reduce the risk of liver cancer, with a more dramatic protective effect for individuals with hepatitis B surface antigen (HBsAg) positive.
Background Little prospective evidence exists about whether a combination of healthy lifestyle factors is related to a considerable reduction of liver cancer risk. Methods Based on the prospective China Kadoorie Biobank (CKB) cohort with a total of 492,640 Chinese adults, we examined the associations of five lifestyle factors with risk of liver cancer. Low-risk lifestyle factors were defined as non-smoking, non-drinking, median or higher level of physical activity, a healthy diet, and waist-to-hip ratio (WHR) < 0.90 for men and Results During a median of 10.12 years of follow-up, 2529 liver cancer events were observed. There was a significant decrease in liver cancer risk with the increasing of the healthy lifestyle index scores (P < 0.001). Participants with a favourable lifestyle (4 or 5 healthy lifestyle factors) had a 43% reduced liver cancer risk compared with those with an unfavourable lifestyle (0 or 1 healthy lifestyle factor) (HR, 0.57 [95% CI, 0.47-0.68]). The cumulative protective effect of a healthy lifestyle on liver cancer appeared to be more dramatic for patients with hepatitis B surface antigen (HBsAg) positive, the individuals at high risk of liver cancer. Conclusions Individuals adhering to a favourable lifestyle was associated with a considerable absolute risk reduction of liver cancer.
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