4.1 Article

Disturbing Lipid Phase Equilibrium in Model Membrane Induced by Lytic Peptides

期刊

BRAZILIAN JOURNAL OF PHYSICS
卷 52, 期 2, 页码 -

出版社

SPRINGER
DOI: 10.1007/s13538-021-01041-z

关键词

Lytic peptides; Lipid-packing perturbation; Domain formation; model membranes

资金

  1. Sao Paulo Research Foundation (FAPESP) [2015/256199, 2015/25620-7]
  2. UNESP
  3. Brazilian Counsil for Scientific and Technological Development (CNPq)

向作者/读者索取更多资源

Lytic peptides disrupt the lipid organization in cell membranes, leading to the loss of cell content.
Lytic peptides are rich in cationic and hydrophobic residues that form amphipathic alpha-helix when in contact with lipid bilayers. Evidence showed that they act on the lipidic phase of the cell membranes, inserting into the lipid core and disturbing the lipid-packing. The insertion creates unbalanced elastic stresses in the outer and inner membrane leaflets that would be relieved by the opening of pores and/or defects and the consequent loss of the cell content. Here we compile results obtained in the investigations of the effects of three peptides on the lipid organization in model membranes whose compositions mimic the target plasma membrane of bacteria and cancer cells to which these peptides demonstrated lytic activity. These peptides have in their sequence the presence of both acidic and basic residues distributed such that they are third and fourth neighbors. We compiled results obtained from previous investigations with these peptides, using two main experimental techniques: lipid monolayers at the constant area and compression isotherms and differential scanning calorimetry. Here, we showed that the peptide-induced lipid packing perturbation was dependent on the structure of the polar head group and on the acyl chain.

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