Anatomy and physiology of word-selective visual cortex: from visual features to lexical processing

Over the past 2 decades, researchers have tried to uncover how the human brain can extract linguistic information from a sequence of visual symbols. The description of how the brain's visual system processes words and enables reading has improved with the progressive refinement of experimental methodologies and neuroimaging techniques. This review provides a brief overview of this research journey. We start by describing classical models of object recognition in non-human primates, which represent the foundation for many of the early models of visual word recognition in humans. We then review functional neuroimaging studies investigating the word-selective regions in visual cortex. This research led to the differentiation of highly specialized areas, which are involved in the analysis of different aspects of written language. We then consider the corresponding anatomical measurements and provide a description of the main white matter pathways carrying neural signals crucial to word recognition. Finally, in an attempt to integrate structural, functional, and electrophysiological findings, we propose a view of visual word recognition, accounting for spatial and temporal facets of word-selective neural processes. This multi-modal perspective on the neural circuitry of literacy highlights the relevance of a posterior-anterior differentiation in ventral occipitotemporal cortex for visual processing of written language and lexical features. It also highlights unanswered questions that can guide us towards future research directions. Bridging measures of brain structure and function will help us reach a more precise understanding of the transformation from vision to language.

Automated summary

This article reviews the research progress over the past 20 years on how the human brain extracts linguistic information from visual symbols. From early models based on non-human primate object recognition to recent functional neuroimaging studies, researchers have delved into the mechanisms of how the brain processes language information. With an integrated approach combining structural, functional, and electrophysiological findings, a more comprehensive view of the neural circuitry involved in visual word recognition has been proposed, highlighting the importance of posterior-anterior differentiation in ventral occipitotemporal cortex for processing written language.