期刊
BRAIN RESEARCH BULLETIN
卷 175, 期 -, 页码 26-36出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2021.07.013
关键词
EMILIN2; Methylation; Immune; Prognostic biomarker; LGG
资金
- National Natural Science Foundation of China [81860664, 81960458, 82060680]
- Technology Research Project of Jiangxi Provincial Department of Education [180077]
- Youth Science Foundation of Science and Technology Department of Jiangxi Provincial [20192BAB215063, 20202BABL216080]
- Clinical Research Projects [2014YNLC12009]
Through bioinformatics analysis, it was found that EMILIN2 may serve as an independent prognostic biomarker in LGG, providing insights into the development and immune infiltration of gliomas.
Low-grade gliomas (LGGs) are slow-growing brain cancer in central nervous system neoplasms. EMILIN2 is an extracellular matrix (ECM) protein which could influence the progress of some tumour which is unclear in LGG. In our study, the methylation, expression, prognosis and immune value of EMILIN2 in LGG were analysed through bioinformatics analysis. We analysed the LGG data from The Cancer Genome Atlas (TCGA) and discovered that the EMILIN2 expression, negatively correlated to the EMILIN2 methylation, could predict a poor prognosis and was associated with different clinical parameters. Moreover, univariate and multivariate Cox regression were performed in CGGA, which showed that the EMILIN2 could be an independent prognostic biomarker in LGG. Moreover, EMILIN2 expression showed a correlation with gene makers in some immune cells, which identified the significance of EMILIN2 in immune infiltration. Finally, we used RT-PCR to verify the EMILIN2 expression level in different grades which showed there were significantly different (P < 0.05). Similarly, high expression of EMILIN2 could predict a poor prognosis (P = 0.0078). In conclusion, EMILIN2 could act as an independent prognostic biomarker which might be associated with the malignancy and development of gliomas and play a crucial role in glioma in immune infiltration.
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