GLIS family zinc finger 3 promoting cell malignant behaviors and NF-KB signaling in glioma

Glioma is a common tumor in the human central nervous system. However, its molecular mechanism in the pathogenesis and regulation of glioma progression is still unclear. In this study, we found that GLIS3 was upregulated in glioma tissues, and the increased expression is positively correlated with advanced tumor grade. Survival evaluation disclosed that patients with high expression levels of GLIS3 normally have a poor prognosis. Functional analysis revealed the oncogenic role of GLIS3 in the development of glioma. GLIS3 promotes glioma cells' invasion, migration, and proliferation. Meanwhile, deficiency of GLIS3 produces an inhibitory function upon NF-KB signaling pathway. This work demonstrated that GLIS3, acting as a target and prognostic factor for glioma, may promote the invasion, migration and proliferation of glioma cells involved in regulation of NF-KB signaling pathway.

Automated summary

The upregulation of GLIS3 in glioma tissues is positively correlated with advanced tumor grade and poor prognosis. GLIS3 plays an oncogenic role in promoting invasion, migration, and proliferation of glioma cells, while also inhibiting the NF-KB signaling pathway.