4.7 Review

Roles of neuronal toll-like receptors in neuropathic pain and central nervous system injuries and diseases

期刊

BRAIN BEHAVIOR AND IMMUNITY
卷 102, 期 -, 页码 163-178

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2022.02.016

关键词

Pain; Alzheimer 's disease; Parkinson 's disease; Psychiatric and mood disorders; Brain injury; Spinal cord injury; Pattern recognition receptors; Toll-like receptors; Innate immunity; Neurodegeneration

资金

  1. New Jersey Commission on Spinal Cord Research Grant [CSCR17IRG007]

向作者/读者索取更多资源

Toll-like receptors (TLRs) are innate immune receptors expressed in immune cells, glia, and neurons, playing important roles in host defense and inflammation. The role of neuronal TLRs in central nervous system diseases and injuries has been underappreciated, and future research is needed to understand their specific contributions in these pathologies.
Toll-like receptors (TLRs) are innate immune receptors that are expressed in immune cells as well as glia and neurons of the central and peripheral nervous systems. They are best known for their role in the host defense in response to pathogens and for the induction of inflammation in infectious and non-infectious diseases. In the central nervous system (CNS), TLRs modulate glial and neuronal functions as well as innate immunity and neuroinflammation under physiological or pathophysiological conditions. The majority of the studies on TLRs in CNS pathologies investigated their overall contribution without focusing on a particular cell type, or they analyzed TLRs in glia and infiltrating immune cells in the context of neuroinflammation and cellular activation. The role of neuronal TLRs in CNS diseases and injuries has received little attention and remains underappreciated. The primary goal of this review is to summarize findings demonstrating the pivotal and unique roles of neuronal TLRs in neuropathic pain, Alzheimer's disease, Parkinson's disease and CNS injuries. We discuss how the current findings warrant future investigations to better define the specific contributions of neuronal TLRs to these pathologies. We underline the paucity of information regarding the role of neuronal TLRs in other neurodegenerative, demyelinating, and psychiatric diseases. We draw attention to the importance of broadening research on neuronal TLRs in view of emerging evidence demonstrating their distinctive functional properties.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据