期刊
BONE
卷 152, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2021.116065
关键词
Glucose-dependent insulinotropic polypeptide (GIP); Glucagon-like peptide-2 (GLP-2); Bone turnover; Gut-bone axis; CTX; P1NP
资金
- Novo Nordisk Foundation [NNF19OC0056951, NNF18CC0034900]
- Novo Nordisk Foundation Center for Basic Metabolic Research
- Novo Nordisk Foundation Center for Basic Metabolic Research is an independent Research Center based at the University of Copenhagen, Denmark
- Michaelsen Foundation
In postmenopausal women, both GIP and GLP-2 individually inhibit bone resorption during nighttime, with complementary effects when combined. GIP rapidly reduces CTX levels within 45-120 minutes post-injection, while GLP-2 has a more delayed effect between 120-240 minutes post-injection.
Background: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are gut hormones secreted in response to food ingestion, and they have been suggested to regulate bone turnover. In humans, exogenous GIP and GLP-2 acutely inhibit bone resorption as measured by circulating levels of carboxyterminal type 1 collagen crosslinks (CTX). Objective: The objective was to study the individual and combined acute effects of GIP and GLP-2 on bone turnover in postmenopausal women during nighttime - a period of increased bone resorption. Methods: Using a randomized, placebo-controlled, double-blinded, crossover design, each participant (n = 9) received on four separate study days: GIP, GLP-2, GIP + GLP-2, and placebo (saline) as subcutaneous injections at bedtime. Main outcomes were levels of CTX and procollagen type 1 N-terminal propeptide (P1NP). Results: Compared with placebo, GIP and GLP-2 alone significantly inhibited bone resorption (measured by CTX). GIP rapidly reduced CTX levels in the period from 45 to 120 min after injection, while GLP-2 had a more delayed effect with reduced CTX levels in the period from 120 to 240 min after injection. Combining GIP and GLP-2 showed complementary effects resulting in a sustained inhibition of CTX with reduced levels from 45 to 240 min after injection. Furthermore, GIP acutely increased bone formation (measured by P1NP). Conclusion: Both GIP and GLP-2 reduced CTX during the night and had complementary effects when combined.
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