4.6 Article

Smaller particular matter, larger risk of female lung cancer incidence? Evidence from 436 Chinese counties

期刊

BMC PUBLIC HEALTH
卷 22, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s12889-022-12622-1

关键词

PM1; PM2; 5; PM10; Lung cancer; China

资金

  1. Start-up Foundation of Fuzhou University [511034]
  2. Education and Science Foundation for Young and Middle-aged Teachers of Fujian Province [JAT210024]
  3. Department of Natural Resources of Fujian Province-Fuzhou University Cooperative Research Project [KY-020000-04-2021-016]
  4. Guangdong -Hong Kong -Macau Joint Laboratory Program of the 2020 Guangdong New Innovative Strategic Research Fund [2020B1212030009]

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This study examines the association between PM1, PM2.5, PM10 and the incidence rate of female lung cancer, and finds that PM1 has the greatest effect. Additionally, the urban-rural division modifies the effects of these three particulate matters.
Background Many studies have reported the effects of PM2.5 and PM10 on human health, however, it remains unclear whether particular matter with finer particle size has a greater effect. Objectives This work aims to examine the varying associations of the incidence rate of female lung cancer with PM1, PM2.5 and PM10 in 436 Chinese cancer registries between 2014 and 2016. Methods The effects of PM1, PM2.5 and PM10 were estimated through three regression models, respectively. Mode l only included particular matter, while Model 2 and Model 3 further controlled for time and location factors, and socioeconomic covariates, respectively. Moreover, two sensitivity analyses were performed to investigate the robustness of three particular matte effects. Then, we examined the modifying role of urban-rural division on the effects of PM1, PM2.5 and PM10, respectively. Results The change in the incidence rate of female lung cancer relative to its mean was 5.98% (95% CI: 3.40, 8.56%) for PM1, which was larger than the values of PM2.5 and PM10 at 3.75% (95% CI: 2.33, 5.17%) and 1.57% (95% CI: 0.73, 2.41%), respectively. The effects of three particular matters were not sensitive in the two sensitivity analyses. Moreover, urban-rural division positively modified the associations of the incidence rate of female lung cancer with PM1, PM2.5 and PM10. Conclusions The effect on the incidence rate of female lung cancer was greater for PM1, followed by PM2.5 and PM10. There were positive modifying roles of urban-rural division on the effects of three particular matters. The finding supports the argument that finer particular matters are more harmful to human health, and also highlights the great significance to develop guidelines for PM1 control and prevention in Chinese setting.

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