4.6 Article

The antimicrobial activity of zinc against group B Streptococcus is strain-dependent across diverse sequence types, capsular serotypes, and invasive versus colonizing isolates

期刊

BMC MICROBIOLOGY
卷 22, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s12866-021-02428-3

关键词

Antimicrobial; Metal; Zinc; Streptococcus agalactiae; Group B Streptococcus

资金

  1. National Institutes of Health [R01 HD090061, R35GM133602, T32 HL007411-36S1, 2T32AI112541-06]
  2. Department of Veterans Affairs Office of Research [BX005352]
  3. NIH [P30DK058404]
  4. National Center for Research Resources [UL1 RR024975-01]
  5. National Center for Advancing Translational Sciences [2 UL1 TR000445-06]

向作者/读者索取更多资源

This study found that the susceptibility or resistance to zinc intoxication in Streptococcus agalactiae strains varies based on their isolation source, capsular serotype, and sequence type. Invasive strains are less susceptible to zinc toxicity compared to colonizing strains. Moreover, capsular type III strains and the ST-17 and ST-19 strains exhibit the greatest resilience to zinc stress.
Background Streptococcus agalactiae or Group B Streptococcus (GBS) is an encapsulated gram-positive bacterial pathobiont that commonly colonizes the lower gastrointestinal tract and reproductive tract of human hosts. This bacterium can infect the gravid reproductive tract and cause invasive infections of pregnant patients and neonates. Upon colonizing the reproductive tract, the bacterial cell is presented with numerous nutritional challenges imposed by the host. One strategy employed by the host innate immune system is intoxication of bacterial invaders with certain transition metals such as zinc. Methodology Previous work has demonstrated that GBS must employ elegant strategies to circumnavigate zinc stress in order to survive in the vertebrate host. We assessed 30 strains of GBS from diverse isolation sources, capsular serotypes, and sequence types for susceptibility or resistance to zinc intoxication. Results Invasive strains, such as those isolated from early onset disease manifestations of GBS infection were significantly less susceptible to zinc toxicity than colonizing strains isolated from rectovaginal swabs of pregnant patients. Additionally, capsular type III (cpsIII) strains and the ST-17 and ST-19 strains exhibited the greatest resilience to zinc stress, whereas ST-1 and ST-12 strains as well as those possessing capsular type Ib (cpsIb) were more sensitive to zinc intoxication. Thus, this study demonstrates that the transition metal zinc possesses antimicrobial properties against a wide range of GBS strains, with isolation source, capsular serotype, and sequence type contributing to susceptibility or resistance to zinc stress.

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