4.4 Article

Long-term hospital-based secondary prevention of coronary artery disease: a randomized controlled trial

期刊

BMC CARDIOVASCULAR DISORDERS
卷 21, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s12872-021-02426-3

关键词

Myocardial infarction; Cardiovascular diseases; Secondary prevention

资金

  1. National Association for Public Health
  2. Sorlandet Hospital HF, Arendal, Norway

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In the field of secondary prevention of cardiovascular events, long-term hospital-based follow-up has shown improvement in composite endpoint-free survival compared to follow-up at primary health care, but did not reduce all-cause mortality significantly. Some important risk factors remain unaddressed despite the beneficial effects on blood pressure and LDL-cholesterol disappearing after annual consultations ceased.
Background and aims Despite established guidelines on secondary prevention of cardiovascular disease, practical implementation of treatment targets is deficient even in high-income countries. This study compared long-term hospital-based treatment with follow-up at primary health care regarding new cardiovascular events and achievement of treatment targets. Methods This randomized controlled trial at Sorlandet Hospital, Norway 2007-2021 included patients hospitalized due to myocardial infarction (n = 760) or after scheduled percutaneous coronary intervention (PCI) (n = 677) or coronary artery bypass grafting (n = 103). Patients were randomized to hospital-based secondary preventive care with consultations 2 weeks, 3 months, 6 months and 1 year after the index event and annually for up to 5 years, or follow-up at primary health care. Final data was collected after 10 years and hazard ratios were calculated using Cox regression analyses. Results Composite endpoint-free survival due to a lower rate of PCI improved in patients with hospital-based follow-up (n = 788) compared to patients followed-up at primary health care (n = 752) (HR 0.80, 95% CI 0.66-0.96; p = 0.02) but all-cause mortality was not reduced (HR 0.96, 95% CI 0.59-1.56; p = 0.86). At 1 year, LDL-cholesterol (2.1 [SD 0.7] versus 2.3 [SD 0.8] mmol/l; p < 0.001) and systolic blood pressure (132 [SD 16] versus 142 [SD 20] mm/Hg; p < 0.001) were lower in the hospital-based group, and the differences remained significant during the first 5 years. Other secondary preventive measures (smoking cessation, physical activity, body weight, glucose control, drug adherence) did not differ. Conclusions Long-term hospital-based secondary preventive follow-up improved composite endpoint-free survival, but not mortality. Substantial risk factors remained unaddressed. The beneficial effects on blood pressure and LDL-cholesterol disappeared after annual consultations ceased. Trial registration: The study is registered in ClinicalTrials.gov (NCT00679237) May 16, 2008.

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