期刊
BMC CARDIOVASCULAR DISORDERS
卷 22, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12872-022-02469-0
关键词
Coronary artery disease; Fractional flow reserve (FFR); AccuiFRct; Instantaneous wave-free ratio (iFR); Physiology
资金
- National Natural Science Foundation of China [81500284]
- Major medical and health science and technology plan of Zhejiang Province [WKJ-ZJ-1913]
- Natural Science Foundation of Zhejiang Province [LY21H020002]
AccuiFRct, a novel CT-iFR method based on deep learning and computational fluid dynamics, showed good correlation with invasive FFR and iFR, demonstrating its potential as a noninvasive tool for detecting ischemia-causing coronary lesions and aiding in clinical decision-making.
Background and objectives Both fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are widely used to evaluate ischemia-causing coronary lesions. A new method of CT-iFR, namely AccuiFRct, for calculating iFR based on deep learning and computational fluid dynamics (CFD) using coronary computed tomography angiography (CCTA) has been proposed. In this study, the diagnostic performance of AccuiFRct was thoroughly assessed using iFR as the reference standard. Methods Data of a total of 36 consecutive patients with 36 vessels from a single-center who underwent CCTA, invasive FFR, and iFR were retrospectively analyzed. The CT-derived iFR values were computed using a novel deep learning and CFD-based model. Results Mean values of FFR and iFR were 0.80 +/- 0.10 and 0.91 +/- 0.06, respectively. AccuiFRct was well correlated with FFR and iFR (correlation coefficients, 0.67 and 0.68, respectively). The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of AccuiFRct <= 0.89 for predicting FFR <= 0.80 were 78%, 73%, 81%, 73%, and 81%, respectively. Those of AccuiFRct <= 0.89 for predicting iFR <= 0.89 were 81%, 73%, 86%, 79%, and 82%, respectively. AccuiFRct showed a similar discriminant function when FFR or iFR were used as reference standards. Conclusion AccuiFRct could be a promising noninvasive tool for detection of ischemia-causing coronary stenosis, as well as facilitating in making reliable clinical decisions.
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