The study identified 3 mature populations of megakaryocytes with different functions, including regulating hematopoietic stem cells, proplatelet formation, and immune responses akin to a monocyte.
In this issue of Blood, Sun et al(1) study megakaryocyte (MK) heterogeneity according to ploidy levels using single cell RNA sequencing (scRNASeq) and found 3 mature MK populations with different functions: 1 regulating hematopoietic stem cells (HSCs), a second involved in proplatelet formation, and a third functioning similar to a monocyte, with innate and adaptive immune responses.
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