CEBPA bZip mutations: just a single shot

In this issue of Blood, Tarlock et al demonstrate that biallelic and single basic-region leucine zipper motif (bZIP) CCAAT enhancer-binding protein a (CEBPA) mutations have an equally favorable prognostic impact in acute myeloid leukemia (AML) in the largest reported series of children, adolescents, and young adults.

Automated summary

In this study, Tarlock and colleagues showed that biallelic and single bZIP CEBPA mutations have similarly favorable prognostic impact in AML in a large cohort of children, adolescents, and young adults.