4.6 Article

Modeling bioaffinity-based targeted delivery of antimicrobials to Escherichia coli biofilms using yeast microparticles. Part II: Parameter evaluation and validation

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Modeling bioaffinity-based targeted delivery of antimicrobials to Escherichia coli biofilms using yeast microparticles. Part I: Model development and numerical simulation

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Summary: This study developed a mechanistic modeling approach to understand the targeted delivery of chlorine to an Escherichia coli biofilm using bioaffinity-based yeast microparticles. Numerical simulations showed that the targeted delivery system achieved a 7 log reduction within 16.2 min, outperforming conventional free chlorine which only achieved a 3.6 log reduction in the same treatment time.

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