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Juan A. Martinez et al.
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BIOTECHNOLOGY JOURNAL (2019)
Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A
Sung Min Son et al.
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Strategic Framework for Parameterization of Cell Culture Models
Pavlos Kotidis et al.
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Bhanu Chandra Mulukutla et al.
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Towards the development of automated fed-batch cell culture processes at microscale
Vincent Wiegmann et al.
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High-resolution 13C metabolic flux analysis
Christopher P. Long et al.
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Yiqun Chen et al.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS (2019)
Utilizing genome-scale models to optimize nutrient supply for sustained algal growth and lipid productivity
Chien-Ting Li et al.
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Parallel comparison of in situ Raman and NIR spectroscopies to simultaneously measure multiple variables toward real-time monitoring of CHO cell bioreactor cultures
Mengyao Li et al.
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Perfusion mammalian cell culture for recombinant protein manufacturing - A critical review
Jean-Marc Bielser et al.
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Segmented linear modeling of CHO fed-batch culture and its application to large scale production
Bassem Ben Yahia et al.
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Selection of chemically defined media for CHO cell fed-batch culture processes
Xiao Pan et al.
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Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
Jong Hyun Kim et al.
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Quality by control: Towards model predictive control of mammalian cell culture bioprocesses
Wolfgang Sommeregger et al.
BIOTECHNOLOGY JOURNAL (2017)
Developing Global Regression Models for Metabolite Concentration Prediction Regardless of Cell Line
Silvere Andre et al.
BIOTECHNOLOGY AND BIOENGINEERING (2017)
Metabolic characterization of a CHO cell size increase phase in fed-batch cultures
Xiao Pan et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2017)
Identification and control of novel growth inhibitors in fed-batch cultures of Chinese hamster ovary cells
Bhanu Chandra Mulukutla et al.
BIOTECHNOLOGY AND BIOENGINEERING (2017)
Cell-controlled hybrid perfusion fed-batch CHO cell process provides significant productivity improvement over conventional fed-batch cultures
Gregory W. Hiller et al.
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A robust feeding strategy to maintain set-point glucose in mammalian fed-batch cultures when input parameters have a large error
Viktor Konakovsky et al.
BIOTECHNOLOGY PROGRESS (2017)
Quick generation of Raman spectroscopy based in-process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture
Brandon N. Berry et al.
BIOTECHNOLOGY PROGRESS (2016)
Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
Julian Lopez-Meza et al.
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Phillip J. White et al.
MOLECULAR METABOLISM (2016)
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Hooman Hefzi et al.
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Macroscopic modeling of mammalian cell growth and metabolism
Bassem Ben Yahia et al.
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Arginine as an Eluent Overcomes the Hindrance of Monoclonal Antibody Quantification by Dextran Sulfate in Protein A Affinity Chromatography
Bong Gyun Kim et al.
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A Single Dynamic Metabolic Model Can Describe mAb Producing CHO Cell Batch and Fed-Batch Cultures on Different Culture Media
Julien Robitaille et al.
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Computational Modeling of Fed-Batch Cell Culture Bioreactor: Hybrid Agent-Based Approach
Elif Seyma Bayrak et al.
IFAC PAPERSONLINE (2015)
The relationship between mTOR signalling pathway and recombinant antibody productivity in CHO cell lines
Raihana Edros et al.
BMC BIOTECHNOLOGY (2014)
Analysis of Chinese hamster ovary cell metabolism through a combined computational and experimental approach
Ning Chen et al.
CYTOTECHNOLOGY (2014)
Glucose concentration control of a fed-batch mammalian cell bioprocess using a nonlinear model predictive controller
Stephen Craven et al.
JOURNAL OF PROCESS CONTROL (2014)
Kinetic models in industrial biotechnology - Improving cell factory performance
Joachim Almquist et al.
METABOLIC ENGINEERING (2014)
Automated dynamic fed-batch process and media optimization for high productivity cell culture process development
Franklin Lu et al.
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The Complex Role of Branched Chain Amino Acids in Diabetes and Cancer
Thomas M. O'Connell
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Computer programs for modeling mammalian cell batch and fed-batch cultures using logistic equations
Chetan T. Goudar
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Ectopic Expression of human mTOR Increases Viability, Robustness, Cell Size, Proliferation, and Antibody Production of Chinese Hamster Ovary Cells
Imke A. J. Dreesen et al.
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High-End pH-Controlled Delivery of Glucose Effectively Suppresses Lactate Accumulation in CHO Fed-Batch Cultures
Matthew Gagnon et al.
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Development of a Mathematical Model for Evaluating the Dynamics of Normal and Apoptotic Chinese Hamster Ovary Cells
Saeideh Naderi et al.
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Simple and efficient control of CHO cell cultures
M. Aehle et al.
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Modeling Kinetics of a Large-Scale Fed-Batch CHO Cell Culture by Markov Chain Monte Carlo Method
Zizhuo Xing et al.
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Maximizing Productivity of CHO Cell-Based Fed-Batch Culture Using Chemically Defined Media Conditions and Typical Manufacturing Equipment
Yao-Ming Huang et al.
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Simpler noninstrumented batch and semicontinuous cultures provide mammalian cell kinetic data comparable to continuous and perfusion cultures
Olivier Henry et al.
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Re-evaluating the Roles of Proposed Modulators of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling
Xuemin Wang et al.
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Kinetics of IFN-γ producing CHO cells and other industrially relevant cell lines in rapeseed-supplemented batch cultures
B. Farges et al.
PROCESS BIOCHEMISTRY (2008)
Hybrid elementary flux analysis/nonparametric modeling: application for bioprocess control
Ana P. Teixeira et al.
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Linking data to models: data regression
Khuloud Jaqaman et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Conversion of a CHO cell culture process from perfusion to fed-batch technology without altering product quality
F. Meuwly et al.
JOURNAL OF BIOTECHNOLOGY (2006)
Logistic equations effectively model mammalian cell batch and fed-batch kinetics by logically constraining the fit
CT Goudar et al.
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The problem of overfitting
DM Hawkins
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