期刊
BIOSENSORS & BIOELECTRONICS
卷 194, 期 -, 页码 -出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2021.113574
关键词
Microfluidic paper-based analytical devices; Preconcentration; Biochemical analysis; Chemical analysis; Ion concentration polarization; Isotachophoresis
类别
资金
- Rachadapisek Sompot Fund for Postdoctoral Fellowship
- Second Century Fund
- Chulalongkorn University, Thailand
Microfluidic paper-based analytical devices (μPADs) have gained attention for their advantages in clinical diagnostics, environmental monitoring, and food safety assurance. However, they lack high sensitivity for detecting trace analytes compared to commercial instruments like mass spectrometry. To enhance sensitivity, a preconcentration step is required. This review focuses on techniques to separate and preconcentrate analytes on μPADs, along with challenges and future perspectives.
Microfluidic paper-based analytical devices (mu PADs) have attracted much attention over the past decade. They embody many advantages, such as abundance, portability, cost-effectiveness, and ease of fabrication, making them superior for clinical diagnostics, environmental monitoring, and food safety assurance. Despite these advantages, mu PADs lack the high sensitivity to detect many analytes at trace levels than other commercial analytical instruments such as mass spectrometry. Therefore, a preconcentration step is required to enhance their sensitivity. This review focuses on the techniques used to separate and preconcentrate the analytes onto the mu PADs, such as ion concentration polarization, isotachophoresis, and field amplification sample stacking. Other separations and preconcentration techniques, including liquid-solid and liquid-liquid extractions coupled with mu PADs, are also reviewed and discussed. In addition, the fabrication methods, advantages, disadvantages, and the performance evaluation of the mu PADs concerning their precision and accuracy were highlighted and critically assessed. Finally, the challenges and future perspectives have been discussed.
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