期刊
BIOSENSORS & BIOELECTRONICS
卷 196, 期 -, 页码 -出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2021.113760
关键词
Wearable biosensor; Screen-printed electrode; Poly (N-phenylglycine); Continuous glucose monitoring; Electrochemical sensor; Interstitial fluid
类别
资金
- Shenzhen Stability Support Plan [20200806163622001]
- National Natural Science Foundation of China [21804007, 21890742]
- SZU Top Ranking Project [86000000210]
Continuous glucose monitoring platform with optimized linear range and long-term stability was developed using a biocompatible conjugated polymer. The system included a small design with signal conditioning, programmable electrochemical chip, and wireless connection. Biocompatibility tests and animal experiments confirmed successful in vivo blood glucose monitoring.
Continuous physiological monitoring is a promising alternative to current chronic disease management for obtaining big data sets to help individualized therapy. Here, we present a continuous glucose monitoring platform consisting of a screen-printed electrochemical biosensor and a fully integrated wireless electrochemical analysis system. A biocompatible conjugated polymer (poly (N-phenylglycine)) was employed as the support material for enzyme immobilization. Specifically, a polyurethane outer layer was decorated onto the working electrode of the biosensor to construct a diffusion limiting membrane and improve the linear range of the glucose sensor. We optimized the fabricated glucose sensor so that it achieves a linear range of 1-30 mM and a sensitivity of 12.69 mu A mM(-1).cm(-2) in vitro. The long-term stability is up to 30 days by storing in PBS solution at 4 degrees C. The overall system design was very small (0.8 x 1.8 cm) and consisted of a signal conditioning part, a programmable electrochemical chip, and a wireless connection using Bluetooth Low Energy with a smartphone. Finally, we carried out biocompatibility tests and animal experiments to demonstrate the device can successfully monitor blood glucose in vivo.
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