期刊
BIOSCIENCE REPORTS
卷 42, 期 1, 页码 -出版社
PORTLAND PRESS LTD
DOI: 10.1042/BSR20210406
关键词
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资金
- Sir Henry Dale Fellowship from the Wellcome Trust
- Royal Society [221818/Z/20/Z]
- Helmholtz Association
- European Research Council StG [948636]
- European Research Council (ERC) [948636] Funding Source: European Research Council (ERC)
- Wellcome Trust [221818/Z/20/Z] Funding Source: Wellcome Trust
This review summarizes the research findings on cardiovirus 2A protein, highlighting its importance and mechanisms in translation, and aims to explore other gene expression strategies mediated by RNA viruses.
Cardioviruses are single-stranded RNA viruses of the family Picornaviridae. In addition to being the first example of internal ribosome entry site (IRES) utilization, cardioviruses also employ a series of alternative translation strategies, such as Stop-Go translation and programmed ribosome frameshifting. Here, we focus on cardiovirus 2A protein, which is not only a primary virulence factor, but also exerts crucial regulatory functions during translation, including activation of viral ribosome frameshifting and inhibition of host cap-dependent translation. Only recently, biochemical and structural studies have allowed us to close the gaps in our knowledge of how cardiovirus 2A is able to act in diverse translation-related processes as a novel RNA-binding protein. This review will summarize these findings, which ultimately may lead to the discovery of other RNA-mediated gene expression strategies across a broad range of RNA viruses.
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