Bisfischoids A and B, dimeric ent-abietane-type diterpenoids with anti-inflammatory potential from Euphorbia fischeriana Steud.

Article Chemistry, Medicinal

Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products

Cheng-Peng Sun et al.

Summary: Soluble epoxide hydrolase (sEH) is a vital protein that plays a crucial role in cardiovascular, central nervous system, and metabolic diseases. Inhibiting sEH may offer potential solutions for the treatment of these diseases.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Chemistry, Organic

Fischdiabietane A, an Antitumoral Diterpenoid Dimer Featuring an Unprecedented Carbon Skeleton from Euphorbia fischeriana

Jun He et al.

Summary: Fischdiabietane A is a novel asymmetric diterpenoid dimer isolated from Euphorbia fischeriana roots, possessing unique ring systems and structures. It exhibits higher activity against T47D cells compared to cisplatin, inducing apoptosis through caspase-3 activation and poly(ADP-ribose) polymerase degradation.

JOURNAL OF ORGANIC CHEMISTRY (2021)

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Review Plant Sciences

Existing knowledge on Euphorbia fischeriana Steud. (Euphorbiaceae): Traditional uses, clinical applications, phytochemistry, pharmacology and toxicology

Ya-Nan Li et al.

Summary: Euphorbia fischeriana has been identified as a toxic herb with medicinal uses for various conditions. A total of 241 chemical constituents have been found in its roots, exhibiting various pharmacological activities, especially anti-tumor, antibacterial, anti-inflammatory, antiviral, and anti-leukemia activities. Further research on its toxicity and pharmacological mechanisms may contribute to the development of more effective lead compounds.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Chemistry, Organic

Euphopias D-F from Euphorbia L.: quantum chemical calculation-based structure elucidation and their bioactivity of inhibiting NLRP3 inflammasome activation

Qiang-Qiang Shi et al.

Summary: Three novel diterpenoids were isolated from Euphorbia helioscopia L., showing potential inhibitory effects on NLRP3 inflammasome. Among them, compound 1 exhibited the ability to inhibit the maturation of caspase-1 and regulate cytokine secretion, potentially blocking cell pyroptosis.

ORGANIC CHEMISTRY FRONTIERS (2021)

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Article Chemistry, Multidisciplinary