期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 145, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.112472
关键词
Myopia; Signaling pathways; Dopamine; Collagen; TGF-beta; HIF-1 alpha
资金
- Natural and Science Foundation of China [11802209]
- Natural Science Foundation of Shandong Province China [ZR2019MA018]
- Shandong Project for Talents Introduction and Development on Youth Innovation Team of Higher Education, China
- Innovation Training Program for College Students of Shan-dong Province China [S202110438018]
- Science and Technology Development Project of Weifang, China [2021YX082]
Myopia has become a critical global health issue due to increasing time spent indoors and genetic susceptibility. Pathological myopia can lead to complications such as retinal detachment and blindness. Signaling pathways such as dopamine and nitric oxide play crucial roles in the development of myopia.
Myopia has become one of the most critical health problems in the world with the increasing time spent indoors and increasing close work. Pathological myopia may have multiple complications, such as myopic macular degeneration, retinal detachment, cataracts, open-angle glaucoma, and severe cases that can cause blindness. Mounting evidence suggests that the cause of myopia can be attributed to the complex interaction of environmental exposure and genetic susceptibility. An increasing number of researchers have focused on the genetic pathogenesis of myopia in recent years. Scleral remodeling and excessive axial elongating induced retina thinning and even retinal detachment are myopia's most important pathological manifestations. The related signaling pathways are indispensable in myopia occurrence and development, such as dopamine, nitric oxide, TGF-beta, HIF-1 alpha, etc. We review the current major and recent progress of biomedicine on myopia-related signaling pathways and mechanisms.
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