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Toward the next-generation phyto-nanomedicines: cell-derived nanovesicles (CDNs) for natural product delivery

期刊

BIOMEDICINE & PHARMACOTHERAPY
卷 145, 期 -, 页码 -

出版社

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.112416

关键词

Cell-derived nanovesicles (CDNs); Extracellular vesicles (EVs); Natural products; Nanoparticles; Delivery

资金

  1. Jimei University [ZQ2018003]
  2. Natural Science Foundation of Fujian Province [2019J05097]
  3. Ministry of Science and Technology [MOST 109-2221-E-005-01]
  4. Kaohsiung Armed Forces General Hospital [KAFGH_D_109014]
  5. National Chung Hsing University [ENABLE: 108ST001B, 110ST001G]
  6. Kasetsart University Joint Research Project [108RA129A]
  7. NCHU-MIRDC Bilateral Joint Research Project [110S0703B]

向作者/读者索取更多资源

Phytochemicals are widely used for therapeutic purposes, and cell-derived nanovesicles show great potential in drug delivery due to their higher stability and superior biocompatibility, which can better encapsulate bioactive molecules.
Phytochemicals are plant-derived bioactive compounds, which have been widely used for therapeutic purposes. Due to the poor water-solubility, low bioavailability and non-specific targeting characteristic, diverse classes of nanocarriers are utilized for encapsulation and delivery of bio-effective agents. Cell-derived nanovesicles (CDNs), known for exosomes or extracellular vesicles (EVs), are biological nanoparticles with multiple functions. Compared to the artificial counterpart, CDNs hold great potential in drug delivery given the higher stability, superior biocompatibility and the lager capability of encapsulating bioactive molecules. Here, we provide a bench-to-bedside review of CDNs-based nanoplatform, including the bio-origin, preparation, characterization and functionalization. Beyond that, the focus is laid on the therapeutic effect of CDNs-mediated drug delivery for natural products. The state-of-art development as well as some pre-clinical applications of using CDNs for disease treatment is also summarized. It is highly expected that the continuing development of CDNs-based delivery systems will further promote the clinical utilization and translation of phyto-nanomedicines.

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