Salidroside attenuates acute lung injury via inhibition of inflammatory cytokine production

Acute lung injury is a fatal condition characterized by excessive inflammation responses. Salidroside, the active constituent of Rhodiola rosea, possesses properties including anti-oxidation, anti-aging, anti-inflammatory, anti-hypoxia, and anti-cancer activities. In the present study, Salidmside attenuated acute lung injury via inhibition of inflammatory cytokine production. Rats pre-treated with Salidroside showed attenuated lipopolysaccharide (LPS)-induced pathological damage and suppressed tumor necrosis factor-alpha (TNF alpha) and interleukin 6 (IL-6) secretion in the lung. Furthermore, flow cytometry showed that Salidroside reduced the production of TNF alpha and IL-6 in NR8383 alveolar macrophages. These findings suggest that Salidroside may attenuate LPS-induced acute lung injury.

Automated summary

Salidroside attenuates acute lung injury by inhibiting inflammatory cytokine production, reducing LPS-induced pathological damage, and suppressing TNF-α and IL-6 secretion in the lung. This suggests that Salidroside may have a potential therapeutic effect in LPS-induced acute lung injury.