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The role of miRNAs in alveolar epithelial cells in emphysema

期刊

BIOMEDICINE & PHARMACOTHERAPY
卷 143, 期 -, 页码 -

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ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.112216

关键词

Emphysema; Alveolar epithelial cells; MiRNA; Biomarkers

资金

  1. Catalyst Award from American Lung Association [R21 ES030808]
  2. [R01 ES032081]
  3. [R01 HL150587]

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COPD is a major cause of mortality and morbidity globally, with exposure to harmful particles like cigarette smoke being a significant risk factor. Pulmonary emphysema, a part of COPD, is characterized by alveolar destruction and enlargement. MiRNAs play an important role in regulating COPD development, acting as potential biomarkers and therapeutics.
Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease becoming one of the leading causes of mortality and morbidity globally. The significant risk factors for COPD are exposure to harmful particles such as cigarette smoke, biomass smoke, and air pollution. Pulmonary emphysema belongs to COPD and is characterized by a unique alveolar destruction pattern resulting in marked airspace enlargement. Alveolar type II (ATII) cells have stem cell potential; they proliferate and differentiate to alveolar type I cells to restore the epithelium after damage. Oxidative stress causes premature cell senescence that can contribute to emphysema development. MiRNAs regulate gene expression, are essential for maintaining ATII cell homeostasis, and their dysregulation contributes to this disease development. They also serve as biomarkers of lung diseases and potential therapeutics. In this review, we summarize recent findings on miRNAs' role in alveolar epithelial cells in emphysema.

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