4.7 Article

Advances in the treatment of Chagas disease: Promising new drugs, plants and targets

期刊

BIOMEDICINE & PHARMACOTHERAPY
卷 142, 期 -, 页码 -

出版社

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.112020

关键词

Chagas disease; Trypanosoma cruzi; New treatments; Drug repurposing; Promising plants; Therapeutics target

资金

  1. Ministerio de Cien-cia, Tecnologia e Innovacion de Colombia-Minciencias [848]

向作者/读者索取更多资源

Chagas disease is currently treated with only two drugs, benznidazole and nifurtimox, which have limitations including efficacy in specific infection stages, adverse effects, and parasite resistance. Some institutions and research groups are exploring new therapeutic alternatives through strategies like dosage modification, drug repurposing, combined therapy, the study of medicinal plants, and identification of essential parasite genes for targeted drug design. Collaboration and knowledge exchange among these entities could lead to the development of innovative treatments for Chagas disease.
Chagas disease, caused by Trypanosoma cruzi, is treated with only two drugs; benznidazole and nifurtimox. These drugs have some disadvantages, including their efficacy only in the acute or early infection phases, adverse effects during their use, and the resistance that the parasite has developed to their activity. Therefore, it is necessary to identify new, safe and effective therapeutic alternatives to treat Chagas disease, though governments and the pharmaceutical industry have shown a lack of interest in contributing to this solution. Institutions and research groups on the other hand have worked on some strategies that can help to address the problem. Some of these include the modification of conventional drug dosages, drug repurposing, and combined therapy. Plants and derived compounds with antiparasitic effects have also been studied, taking advantage of traditional medicinal knowledge. Others have studied the parasite to identify essential genes that can be used as therapeutic targets to design new, targeted drugs. Some of these studies have generated promising results, but few reach clinical phase studies. Institutions and research groups should be encouraged to unify efforts and cover all aspects of drug development according to resources and knowledge availability. In the end, this exchange of knowledge would lead to the development of new therapeutic alternatives to treat Chagas disease and benefit the populations it affects.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据