4.7 Article

Impact of early interferon-β treatment on the prognosis of patients with COVID-19 in the first wave: A post hoc analysis from a multicenter cohort

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BIOMEDICINE & PHARMACOTHERAPY
卷 146, 期 -, 页码 -

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ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.112572

关键词

Interferon-beta; Treatment; COVID-19; SARS-CoV-2; Mortality

资金

  1. Fundacion SEIMC/GeSIDA [COVID-19/SEIMC-FSG]
  2. Plan Nacional de I+D+i 2013-2016
  3. Instituto de Salud Carlos III
  4. Subdireccion General de Redes y Centros de Investigacion Cooperativa
  5. Ministerio de Ciencia, Innovacion y Universidades
  6. European Development Regional Fund A way to achieve Europe from the CIBER de Enfermedades Infecciosas (CIBERINFEC) [RD16CIII/0002/0006, RD16/0025/0017, RD16/0025/0018, RD16/0016/0001, RD16/0016/0005, RD16/0016/0009, CB21/13/00091, CB21/13/00044, CB21/13/00039, CB21/13/00012, CB21/13/00009]
  7. European Development Regional Fund

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In this multicenter cohort of admitted COVID-19 patients, receiving early interferon-beta therapy after hospital admission did not show an association with lower mortality. Whether interferon-beta might be useful in the earlier stages of the disease or specific subgroups of patients requires further research.
Background: Interferon-p is an attractive drug for repurposing and use in the treatment of COVID-19, based on its in vitro antiviral activity and the encouraging results from clinical trials. The aim of this study was to analyze the impact of early interferon-p treatment in patients admitted with COVID-19 during the first wave of the pandemic. Methods: This post hoc analysis of a COVID-19@Spain multicenter cohort included 3808 consecutive adult patients hospitalized with COVID-19 from 1 January to 17 March 2020. The primary endpoint was 30-day all-cause mortality, and the main exposure of interest was subcutaneous administration of interferon-beta, defined as early if started <= 3 days from admission. Multivariate logistic and Cox regression analyses were conducted to identify the associations of different variables with receiving early interferon-beta therapy and to assess its impact on 30-day mortality. A propensity score was calculated and used to both control for confounders and perform a matched cohort analysis. Results: Overall, 683 patients (17.9%) received early interferon-p therapy. These patients were more severely ill. Adjusted HR for mortality with early interferon-p was 1.03 (95% CI, 0.82-1.30) in the overall cohort, 0.96 (0.82-1.13) in the PS-matched subcohort, and 0.89 (0.60-1.32) when interferon-beta treatment was analyzed as a time-dependent variable. Conclusions: In this multicenter cohort of admitted COVID-19 patients, receiving early interferon-beta therapy after hospital admission did not show an association with lower mortality. Whether interferon-beta might be useful in the earlier stages of the disease or specific subgroups of patients requires further research.

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