期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 142, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.111970
关键词
Chitosan; TPP; Ionic gelation; Nanoparticles; Polyphenols; Nutraceuticals
资金
- ANPCyT PICT [2015-3866, 2017-1683]
- Universidad de Buenos Aires UBACyT [20020190100297BA]
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
Plant-based polyphenols are natural compounds found in fruits and vegetables, known for their nutraceutical and pharmacological activities. However, their photosensitivity, low bioavailability, rapid metabolism, and short biological half-life present major limitations for their use, which can be overcome by encapsulating polyphenols into chitosan-tripolyphosphate based nanoparticles.
Plant-based polyphenols are natural compounds, present in fruits and vegetables. During recent years, poly phenols have gained special attention due to their nutraceutical and pharmacological activities for the prevention and treatment of human diseases. Nevertheless, their photosensitivity and low bioavailability, rapid metabolism and short biological half-life represent the major limitations for their use, which could be overcome by polyphenols encapsulation (flavonoids and non-flavonoids) into chitosan (CS)-tripolyphosphate (TPP) based nanoparticles (NP). In this review, we particularly focused on the ionic gelation method for the NP design. This contribution exhaustively discusses and compares results of scientific reports published in the last decade referring to ionic gelation applied for the protection, controlled and site-directed delivery of polyphenols. As a consequence, CS-TPP NP would constitute true platforms to transport polyphenols, or a combination of them, to be used for the designing of a new generation of drugs or nutraceuticals.
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