期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 142, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2020.111196
关键词
Plant extract; Atherosclerosis; Low density lipoprotein; Reactive species; J774 macrophages
资金
- FAPERGS/CNPq/PRONEX [16/2551-0000 499-4]
- Pronem
- CAPES
- CNPq-Brazil
- CNPq
Syzigium cumini leaf extract (ScExt) has shown to protect macrophages from oxLDL-mediated toxicity by preventing overproduction of reactive oxygen/nitrogen species and foam cell formation induced by oxLDL. These protective effects make ScExt a promising antioxidant for future trials in atherosclerosis prevention.
Oxidized LDL (oxLDL) plays a pivotal role on atherosclerosis development, mainly in the formation of lipid-laden macrophage foam cells. As a consequence, substances that can modulate LDL oxidation have a pharmacological and therapeutic relevance. Based in previous findings showing the ability of Syzigium cumini leaf extract (ScExt) in preventing LDL oxidation in vitro, this study was aimed to assess the effects of ScExt on oxLDL-mediated toxicity in murine J774 macrophages-like cells. For biochemical analyses, LDL isolated from fresh human plasma and oxidized with CuSO4 was incubated with ScExt pre-treated macrophages. Our results demonstrated that ScExt was efficient in preventing the overproduction of reactive oxygen/nitrogen species (ROS/RNS), the loss of macrophage's viability and the foam cells formation induced by oxLDL. These protective effects of ScExt make it a promising antioxidant for future trials toward atherogenesis.
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