期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 142, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.112040
关键词
Male fertility; Cisplatin; Doxorubicin; Paclitaxel; 5-Fluorouracil; Cyclophosphamide
资金
- shahid beheshti university of medical sciences
The treatment of cancer in young adults can have detrimental effects on the reproductive system, particularly on male germ cells. Lack of appropriate fertility preservation treatments in affected children calls for the introduction of methods to mitigate the harmful effects of chemotherapeutic agents, including the potential protective effects of antioxidants.
Treatment of cancer in young adults is associated with several side effects, particularly in the reproductive system. Detrimental effects of chemotherapy on the germ cells depend on many factors including primary semen parameters, the way of drug administration, the kind and dose of chemotherapeutic regimens, and the phase of spermatogenesis during the time of drug administration. Lack of appropriate fertility preservation treatments particularly in the affected children necessitates the introduction of methods to amend the harmful effects of chemotherapeutic agents on male germ cells. Several studies have assessed the toxic effects of chemotherapeutic agents in rodent models and tested a number of antioxidants to evaluate their possible impact on the preservation of sperm cells. In the present manuscript, we describe the effects of the mostly investigated chemotherapeutic drugs in this regard i.e., cisplatin, doxorubicin, paclitaxel, 5-fluorouracil, and cyclophosphamide. As several in vivo and in vitro studies have shown the impact of antioxidants on chemotherapy-induced damage of sperms, we also describe the protective effects of antioxidants in this regard.
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