4.7 Article

AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation

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PHYTOMEDICINE (2021)

Article Pharmacology & Pharmacy

Cinacalcet as a surrogate therapy for diabetic cardiomyopathy in rats through AMPK-mediated promotion of mitochondrial and autophagic function

Rania A. Elrashidy et al.

Summary: Decreased AMP-activated protein kinase (AMPK) activity is associated with diabetic cardiomyopathy (DCM). Cinacalcet appears to activate AMPK and improve cardiac remodeling and dysfunction in a dose-dependent manner in type 2 diabetic rats (T2DM). Additionally, Cinacalcet does not affect blood glucose levels, but increases mitochondrial DNA content and expression of key proteins involved in cellular processes.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Kun-Dan Decoction Ameliorates Insulin Resistance by Activating AMPK/mTOR-Mediated Autophagy in High-Fat Diet-Fed Rats

Zuqing Su et al.

Summary: KD has been shown to improve metabolic syndrome by activating autophagy, enhancing insulin sensitivity, reducing obesity, serum lipid levels, and increasing HDL-C levels, providing a potential treatment option for patients with metabolic syndrome.

FRONTIERS IN PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system

Udayakumar Karunakaran et al.

Summary: Brief Summary: The study demonstrates that pioglitazone selectively protects beta cells against high glucose-induced dysfunction by activating the AMPK and GLS1 axis, resulting in elevated GSH/GSSG ratio and inhibition of mitochondrial dysfunction.

REDOX BIOLOGY (2021)

Article Biology

α,β-Amyrin prevents steatosis and insulin resistance in a high-fat diet-induced mouse model of NAFLD via the AMPK-mTORC1-SREBP1 signaling mechanism

R. P. de Lima et al.

Summary: The study showed that α, β-amyrin could alleviate hepatic steatosis and inflammation in NAFLD mice by modulating the AMPK-mTORC1-SREBP1 signaling pathway.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2021)

Article Integrative & Complementary Medicine

Ginsenoside Rh1 Improves Type 2 Diabetic Nephropathy through AMPK/PI3K/Akt-Mediated Inflammation and Apoptosis Signaling Pathway

Wen-Ya Su et al.

Summary: This study evaluates the ameliorative effects of ginsenoside Rh1 on obesity-linked diabetic nephropathy induced by high fat diet and streptozotocin. The results suggest that G-Rh1 shows potential in improving treatment of DN.

AMERICAN JOURNAL OF CHINESE MEDICINE (2021)

Article Biochemistry & Molecular Biology

Vitexin, a fenugreek glycoside, ameliorated obesity-induced diabetic nephropathy via modulation of NF-κB/IkBα and AMPK/ACC pathways in mice

Guangju Zhou et al.

Summary: The study demonstrated that vitexin suppressed the progression of obesity-induced diabetic nephropathy by modulating the NF-kappa B/IκBα and AMPK/ACC pathways in an experimental model of HFD-induced DN in C57BL/6J mice.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Soluble epoxide hydrolase inhibitor protects against blood-brain barrier dysfunction in a mouse model of type 2 diabetes via the AMPK/HO-1 pathway

Jing Wu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Salidroside ameliorates diabetic nephropathy in rats by activating renal AMPK/SIRT1 signaling pathway

Ali A. Shati

JOURNAL OF FOOD BIOCHEMISTRY (2020)

Article Pharmacology & Pharmacy

Oleoylethanolamide Increases Glycogen Synthesis and Inhibits Hepatic Gluconeogenesis via the LKB1/AMPK Pathway in Type 2 Diabetic Model

Tong Ren et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2020)

Review Chemistry, Medicinal

Therapeutic effects of kaempferol affecting autophagy and endoplasmic reticulum stress

Milad Ashrafizadeh et al.

PHYTOTHERAPY RESEARCH (2020)

Article Biotechnology & Applied Microbiology

Crocin Improves Insulin Sensitivity and Ameliorates Adiposity by Regulating AMPK-CDK5-PPARγSignaling

Kai Fang et al.

BIOMED RESEARCH INTERNATIONAL (2020)

Article Biochemistry & Molecular Biology

Effects of metformin and pioglitazone combination on apoptosis and AMPK/mTOR signaling pathway in human anaplastic thyroid cancer cells

Nilufer Ozdemir Kutbay et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2020)

Article Medicine, Research & Experimental

Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction

Wen-Qiao Qiu et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Biochemistry & Molecular Biology

Epigenetic modification and therapeutic targets of diabetes mellitus

Rajveer Singh et al.

BIOSCIENCE REPORTS (2020)

Article Neurosciences

AMPK Ameliorates Tau Acetylation and Memory Impairment Through Sirt1

Lin Wang et al.

MOLECULAR NEUROBIOLOGY (2020)

Article Pharmacology & Pharmacy

Sensing the scent of death: Modulation of microRNAs by Curcumin in gastrointestinal cancers

Milad Ashrafizadeh et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Biochemistry & Molecular Biology

CCAL1 enhances osteoarthritis through the NF-κB/AMPK signaling pathway

Hanzhong Zhu et al.

FEBS OPEN BIO (2020)

Article Endocrinology & Metabolism

Assessment of Cell-Free Long Non-Coding RNA-H19 and miRNA-29a, miRNA-29b Expression and Severity of Diabetes

Mohammed Alfaifi et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2020)

Review Biochemistry & Molecular Biology

Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives

Ebrahim Rahmani Moghadam et al.

BIOMOLECULES (2020)

Article Biochemistry & Molecular Biology

Photobiomodulation reduces hepatic lipogenesis and enhances insulin sensitivity through activation of CaMKKβ/AMPK signaling pathway

Shuang Guo et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2020)

Review Medicine, Research & Experimental

Insulin resistance and bioenergetic manifestations: Targets and approaches in Alzheimer's disease

Vivek Kumar Sharma et al.

LIFE SCIENCES (2020)

Article Biochemistry & Molecular Biology

Tankyrase inhibition augments neuronal insulin sensitivity and glucose uptake via AMPK-AS160 mediated pathway

Kapil Manglani et al.

NEUROCHEMISTRY INTERNATIONAL (2020)

Article Endocrinology & Metabolism

Circulating miR-30a-5p and miR-182-5p in Prediabetes and Screen-Detected Diabetes Mellitus

Cecil Jack Weale et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2020)

Review Biochemistry & Molecular Biology

Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease

Florian Juszczak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Evaluation of Interleukin-23 and JAKs/STATs/SOCSs/ROR-γt Expression in Type 2 Diabetes Mellitus Patients Treated With or Without Sitagliptin

Mahsa Rezaeepoor et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2020)

Review Peripheral Vascular Disease

Insulin Resistance the Hinge Between Hypertension and Type 2 Diabetes

Costantino Mancusi et al.

HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION (2020)

Article Pharmacology & Pharmacy

Vaccarin ameliorates insulin resistance and steatosis by activating the AMPK signaling pathway

Yueyue Lei et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Article Endocrinology & Metabolism

Aldose reductase regulates hyperglycemia-induced HUVEC death via SIRT1/AMPK-α1/mTOR pathway

Pabitra B. Pal et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2019)

Article Medicine, Research & Experimental

Pancreastatin inhibitor activates AMPK pathway via GRP78 and ameliorates dexamethasone induced fatty liver disease in C57BL/6 mice

Anand P. Gupta et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Medicine, Research & Experimental

mTORC1-to-AMPK switching underlies β cell metabolic plasticity during maturation and diabetes

Rami Jaafar et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Biochemistry & Molecular Biology

AMPK α1 mediates the protective effect of adiponectin against insulin resistance in INS-1 pancreatic β cells

Yan Wang et al.

CELL BIOCHEMISTRY AND FUNCTION (2019)

Article Endocrinology & Metabolism

Naringenin improves insulin sensitivity in gestational diabetes mellitus mice through AMPK

Sen Li et al.

NUTRITION & DIABETES (2019)

Article Food Science & Technology

Hypoglycemic effect of whole grain diet in C57BL/KsJ-db/db mice by activating PI3K/Akt and AMPK pathways

Changhee Kim et al.

FOOD SCIENCE AND BIOTECHNOLOGY (2019)

Article Endocrinology & Metabolism

Exendin-4 Protects against Hyperglycemia-Induced Cardiomyocyte Pyroptosis via the AMPK-TXNIP Pathway

Hong Wei et al.

JOURNAL OF DIABETES RESEARCH (2019)

Article Biochemistry & Molecular Biology

Sirt6 Suppresses High Glucose-Induced Mitochondrial Dysfunction and Apoptosis in Podocytes through AMPK Activation

Yanqin Fan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

Review Cell Biology

AMPK: guardian of metabolism and mitochondrial homeostasis

Sebastien Herzig et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Fibroblast growth factor 19 protects the heart from oxidative stress-induced diabetic cardiomyopathy via activation of AMPK/Nrf2/HO-1 pathway

Xin Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Pharmacology & Pharmacy

Didymin prevents hyperglycemia-induced human umbilical endothelial cells dysfunction and death

Kirtikar Shukla et al.

BIOCHEMICAL PHARMACOLOGY (2018)

Article Endocrinology & Metabolism

Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day

Mary Courtney Moore et al.

DIABETES (2018)

Article Biochemistry & Molecular Biology

Low molecular weight fucoidan attenuates liver injury via SIRTI/AMPK/PGC1 alpha axis in db/db mice

Yuanyuan Zheng et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Article Endocrinology & Metabolism

FNDC5 attenuates adipose tissue inflammation and insulin resistance via AMPK-mediated macrophage polarization in obesity

Xiao-Qing Xiong et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2018)

Review Clinical Neurology

Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Melanie D. Sweeney et al.

NATURE REVIEWS NEUROLOGY (2018)

Article Medicine, General & Internal

Compound K attenuates glucose intolerance and hepatic steatosis through AMPK-dependent path-ways in type 2 diabetic OLETF rats

Yoo-Cheol Hwang et al.

KOREAN JOURNAL OF INTERNAL MEDICINE (2018)

Article Biochemistry & Molecular Biology

Astragalus Polysaccharide Improves Insulin Sensitivity via AMPK Activation in 3T3-L1 Adipocytes

Ruixin Zhang et al.

MOLECULES (2018)

Article Biochemistry & Molecular Biology

METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPAR delta-dependent pathways in skeletal muscle of mice

Tae Woo Jung et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

Article Cell Biology

LncRNA KCNQ1OT1 Mediates Pyroptosis in Diabetic Cardiomyopathy

Fan Yang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Article Immunology

Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK

Gang Liu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2017)

Article Medicine, Research & Experimental

Mulberry granules protect against diabetic cardiomyopathy through the AMPK/Nrf2 pathway

Yang Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

Article Endocrinology & Metabolism

5-ALA ameliorates hepatic steatosis through AMPK signaling pathway

Haoyong Yu et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2017)

Review Endocrinology & Metabolism

Regulation of hepatic glucose metabolism in health and disease

Max C. Petersen et al.

NATURE REVIEWS ENDOCRINOLOGY (2017)

Article Endocrinology & Metabolism

Glycyrrhizic Acid Prevents Diabetic Nephropathy by Activating AMPK/SIRT1/PGC-1α Signaling in db/db Mice

Shaozhang Hou et al.

JOURNAL OF DIABETES RESEARCH (2017)

Article Pharmacology & Pharmacy

Salidroside, A Natural Antioxidant, Improves β-Cell Survival and Function via Activating AMPK Pathway

Linjie Ju et al.

FRONTIERS IN PHARMACOLOGY (2017)

Article Integrative & Complementary Medicine

Anti-diabetic effect of black ginseng extract by augmentation of AMPK protein activity and upregulation of GLUT2 and GLUT4 expression in db/db mice

Ok-Hwa Kang et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)

Review Cell Biology

AMPK signalling in health and disease

David Carling

CURRENT OPINION IN CELL BIOLOGY (2017)

Article Endocrinology & Metabolism

Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner

Rui Wei et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2016)

Editorial Material Endocrinology & Metabolism

Current prevalence of Type 1 and Type 2 diabetes in adults and children in the UK

N. Holman et al.

DIABETIC MEDICINE (2015)

Article Multidisciplinary Sciences

Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway

Kumsun Cho et al.

SCIENTIFIC REPORTS (2015)

Article Neurosciences

Metformin Treatment Alters Memory Function in a Mouse Model of Alzheimer's Disease

Kacee A. DiTacchio et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

Article Multidisciplinary Sciences

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

Rachel J. Perry et al.

NATURE (2014)

Article Endocrinology & Metabolism

Glucose-6-Phosphate-Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis

Alexander von Wilamowitz-Moellendorff et al.

DIABETES (2013)

Review Biochemistry & Molecular Biology

Oxidative Stress in Diabetes: Implications for Vascular and Other Complications

Dario Pitocco et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Article Multidisciplinary Sciences

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

Russell A. Miller et al.

NATURE (2013)

Review Physiology

MECHANISMS OF DIABETIC COMPLICATIONS

Josephine M. Forbes et al.

PHYSIOLOGICAL REVIEWS (2013)

Article Biochemistry & Molecular Biology

Creatine-induced glucose uptake in type 2 diabetes: a role for AMPK-α?

Christiano Robles Rodrigues Alves et al.

AMINO ACIDS (2012)

Review Clinical Neurology

Diabetic neuropathy: clinical manifestations and current treatments

Brian C. Callaghan et al.

LANCET NEUROLOGY (2012)

Review Clinical Neurology

Diabetes, hyperglycaemia, and acute ischaemic stroke

Merel J. A. Luitse et al.

LANCET NEUROLOGY (2012)

Review Biochemistry & Molecular Biology

AMPK inhibition in health and disease

Benoit Viollet et al.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2010)

Article Endocrinology & Metabolism

Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications

Corey E. Tabit et al.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2010)

Article Endocrinology & Metabolism

被撤回的出版物: UCF-101 mitigates streptozotocin-induced cardiomyocyte dysfunction: role of AMPK (Retracted article. See vol. 323, 2022)

Qun Li et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)

Article Agriculture, Multidisciplinary

Epigallocatechin Gallate (EGCG) and Rutin Suppress the Glucotoxicity through Activating IRS2 and AMPK Signaling in Rat Pancreatic β Cells

Erica P. Cai et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2009)

Review Microbiology

Pyroptosis: host cell death and inflammation

Tessa Bergsbaken et al.

NATURE REVIEWS MICROBIOLOGY (2009)

Review Clinical Neurology

Diabetic neuropathy - a review

Gerard Said

NATURE CLINICAL PRACTICE NEUROLOGY (2007)

Review Hematology

Lipid inflammatory mediators in diabetic vascular disease

R Natarajan et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2004)

Article Endocrinology & Metabolism

Diabetic retinopathy

DS Fong et al.

DIABETES CARE (2003)

Article Medicine, Research & Experimental

Role of AMP-activated protein kinase in mechanism of metformin action

GC Zhou et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)

Article Endocrinology & Metabolism

Socio-economic status, obesity and prevalence of Type 1 and Type 2 diabetes mellitus

JMM Evans et al.

DIABETIC MEDICINE (2000)