A general in-situ reduction method to prepare core-shell liquid-metal/metal nanoparticles for photothermally enhanced catalytic cancer therapy

Gallium indium (GaIn) alloy as a kind of liquid metal (LM) with unique chemical and physical properties has attracted increasing attention for its potential biomedical applications. Herein, a series of core-shell GaIn@Metal (Metal: Pt, Au, Ag, and Cu) heterogeneous nanoparticles (NPs) are obtained by a simple in-situ reduction method. Take core-shell GaIn@Pt NPs for example, the synthesized GaIn@Pt NPs after Pt growth on their surface showed significantly improved photothermal conversion efficiency (PCE) and thermal stability under near-infrared (NIR) II light irradiation. Moreover, the core-shell GaIn@Pt NPs also exhibited good Fenton-like catalytic effect due to the presence of Pt on their surface, and could convert tumor endogenous H2O2 to generate reactive oxygen species (ROS) for cancer cell killing. With biocompatible polyethylene glycol (PEG) modification, such GaIn@PtPEG NPs showed efficient tumor homing after intravenous injection, and could lead to effective NIR II triggered photothermal-chemodynamic synergistic therapy of tumors as evidenced in a mouse tumor model. Our work highlights the ingenious use of the chemical properties of metals, providing a rather simple route for the surface engineering of LM-based multifunctional nanoplatforms to achieve a variety of functionalities.

Automated summary

In this study, a series of core-shell GaIn@Metal heterogeneous nanoparticles were obtained by a simple in-situ reduction method. Among them, the core-shell GaIn@Pt NPs showed significantly improved photothermal conversion efficiency and exhibited good Fenton-like catalytic effect. With PEG modification, these NPs displayed efficient tumor homing and effective NIR II triggered photothermal-chemodynamic synergistic therapy in a mouse tumor model.