期刊
BIOMACROMOLECULES
卷 23, 期 3, 页码 789-797出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.1c01209
关键词
-
资金
- Kyoto University Nano Technology Hub in Nanotechnology Platform Project - Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
Antiviral lignin produced by acidic microwave glycerolysis of sugarcane bagasse exhibits antiviral activity against both nonenveloped and enveloped viruses. The lignin prepared at 200°C showed the strongest antiviral activity and inhibited viral entry to host cells through interactions with the capsid surface.
Antiviral lignin was produced by acidic microwave glycerolysis of sugarcane bagasse. The lignin exhibited antiviral activity against nonenveloped (encephalomyocarditis virus (EMCV) and Theiler's murine encephalomyelitis virus (TMEV)) and enveloped (vesicular stomatitis virus (VSV), Sindbis virus (SINV), and Newcastle disease virus (NDV)) viruses. A series of lignins with different antiviral activities were prepared by reacting bagasse at 140, 160, 180, and 200 & DEG;C to analyze the antiviral mechanism. No difference in zeta-potential was observed among the lignin preparations; however, the lignin prepared at 200 & DEG;C (FR200) showed the strongest anti-EMCV activity, smallest hydrodynamic diameter, highest hydro-philicity, and highest affinity for EMCV. FR200 inhibited viral propagation through contact with the virion at the attachment stage to host cells, and the EMCV RNA was intact after treatment. Therefore, the lignin inhibits viral entry to host cells through interactions with the capsid surface. The nonvolatile antiviral substance is potentially useful for preventing the spread of viruses in human living and livestock breeding environments.
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