期刊
BIOMACROMOLECULES
卷 22, 期 12, 页码 4933-4944出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.1c00731
关键词
-
资金
- National Institutes of Health National Institute on Deafness and Other Communication Disorders [NIHDC016644]
- Department of the Navy, Office of Naval Research [N00014-20-1-2418]
- National Science Foundation Graduate Research Fellowship Program [DGE-1650441]
- NSF MRSEC program [DMR-1719875]
The study reported the design of insoluble pyridine-rich polymer surfaces synthesized using initiated chemical vapor deposition, which successfully modulated biofilm growth and virulence in Pseudomonas aeruginosa. This research indicates a rich potential for materials-based strategies to direct the behavior of naturally occurring biofilms.
Biofilms are ubiquitous in nature, yet strategies to direct biofilm behavior without genetic manipulation are limited. Due to the small selection of materials that have been used to successfully grow biofilms, the availability of functional materials that are able to support growth and program microbial functions remains a critical bottleneck in the design and deployment of functional yet safe microbes. Here, we report the design of insoluble pyridine-rich polymer surfaces synthesized using initiated chemical vapor deposition, which led to modulated biofilm growth and virulence in Pseudomonas aeruginosa (PAO1). A variety of extracellular virulence factors exhibited decreased production in response to the functional polymer, most significantly biomolecules also associated with iron acquisition, validating the material design strategy reported here. This report signifies a rich potential for materials-based strategies to direct the behavior of naturally occurring biofilms, which complement the existing genetic engineering toolkits in advancing microbiology, translational medicine, and biomanufacturing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据