4.5 Article

Prostaglandin E2 receptor 3 promotes M1 macrophages polarization in unexplained recurrent pregnancy loss

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Summary: The study demonstrates that trophoblasts induce M2 macrophages polarization via the IL-6/Stat3 signaling pathway, thereby promoting trophoblast invasion and migration. These results reveal the interaction between macrophages and trophoblasts in the maternal-fetal microenvironment during normal pregnancy.

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