期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 44, 期 10, 页码 1391-1398出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.b21-00453
关键词
blood vessel; brain; cancer; drug delivery; microbubble; ultrasound
资金
- ACRO Incubation Grants of Teikyo University
Enhancing vascular permeability using ultrasound and microbubbles can improve drug transport to targeted tissues, offering potential therapeutic benefits for a variety of diseases. This approach shows promise in various tissues and drugs applications.
Ultrasound and microbubbles, an ultrasound contrast agent, have recently increased attention to developing novel drug delivery systems. Ultrasound exposure can induce mechanical effects derived from microbubbles behaviors such as an expansion, contraction, and collapse depending on ultrasound conditions. These mechanical effects induce several biological effects, including enhancement of vascular permeability. For drug delivery, one promising approach is enhancing vascular permeability using ultrasound and microbubbles, resulting in improved drug transport to targeted tissues. This approach is applied to several tissues and drugs to cure diseases. This review describes the enhancement of vascular permeability by ultrasound and microbubbles and its therapeutic application, including our recent study. We also discuss the current situation of the field and its potential future perspectives.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据