期刊
BIOGERONTOLOGY
卷 23, 期 2, 页码 201-213出版社
SPRINGER
DOI: 10.1007/s10522-022-09955-0
关键词
Diosgenin; Anti-aging; Antioxidation; Rejuvenation; Oxidative stress
资金
- National Natural Science Foundation of China [32073000]
- Ministry of Science and Technology [2018YFD0900505]
This study demonstrates for the first time the rejuvenation and anti-aging property of the naturally occurring steroidal sapogenin DG. DG intake extends lifespan, reduces the accumulation of aging markers, and lowers oxidative stress levels through modulation of multiple signaling pathways.
Oxidative stress including DNA damage, increased lipid and protein oxidation, is an important feature of aging. Diosgenin (DG) has been shown to have diverse biological effects, including amelioration of aging-related cognition deficits, but the anti-aging activity of DG has not been tested before in animal models. In the present study, we clearly demonstrated that dietary intake of DG extended both mean and maximum lifespans of the male fish Nothobranchius guentheri by approximately 3.23 and 3.67 weeks, respectively, reduced the accumulation of lipofuscin (LF) in the gills and senescence-associated-beta-galactosidase (SA-beta-Gal) in the caudal fins, and lowered the levels of protein oxidation, lipid peroxidation and reactive oxygen species (ROS) in the muscles, indicating that DG possesses rejuvenation and anti-aging property. We also showed that DG enhanced the activity of antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase, promoted the proteolytic activity of the ubiquitin-proteasome pathway, and suppressed the phosphatidylinositol 3-kinase/protein kinase/molecular target of rapamycin (PI3K/AKT/mTOR) signaling pathway. Altogether, this study highlights for the first time the rejuvenation and anti-aging property of the naturally occurring steroidal sapogenin DG. It also suggests that DG exerts its rejuvenation and anti-aging activity through modulation of multiple signaling pathways that play prominent roles in ROS production.
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