4.6 Article

Daidzin inhibits hepatocellular carcinoma survival by interfering with the glycolytic/gluconeogenic pathway through downregulation of TPI1

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Plant Sciences

Coptis chinensis and dried ginger herb combination inhibits gastric tumor growth by interfering with glucose metabolism via LDHA and SLC2A1

Min Fu et al.

Summary: The combination of Coptis chinensis and dried ginger inhibits the proliferation, migration, and invasion of gastric cancer cells by regulating glucose metabolism through LDHA and SLC2A1 genes, thus suppressing tumorigenesis.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Article Gastroenterology & Hepatology

TAZ is indispensable for c-MYC-induced hepatocarcinogenesis

Haichuan Wang et al.

Summary: TAZ is identified as a pivotal player at the crossroad between the c-MYC and Hippo pathways in HCC, playing a critical role in c-MYC-dependent hepatocarcinogenesis and potentially being targeted for the treatment of c-MYC-driven hepatocellular carcinoma patients.

JOURNAL OF HEPATOLOGY (2022)

Article Cell Biology

Andrographolide ameliorates aortic valve calcification by regulation of lipid biosynthesis and glycerolipid metabolism targeting MGLL expression in vitro and in vivo

Chunli Wang et al.

Summary: The basic research on the disease indicates that AGP can attenuate the calcification of aortic valves by regulating cell metabolism. Metabolome analysis revealed highly enriched metabolites associated with calcification, and AGP significantly suppressed the accumulation of these metabolites by inhibiting VICs calcific differentiation. The in vitro and in vivo results confirmed the effectiveness of AGP in ameliorating aortic valve calcification by targeting lipid biosynthesis and glycerolipid metabolism.

CELL CALCIUM (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Cell Biology

PPM1G promotes the progression of hepatocellular carcinoma via phosphorylation regulation of alternative splicing protein SRSF3

Dawei Chen et al.

Summary: The protein phosphatase PPM1G plays a crucial role in regulating the phosphorylation of SRSF3 in hepatocellular carcinoma (HCC), affecting HCC proliferation, invasion, and metastasis. Higher levels of PPM1G in HCC tissues are correlated with poor prognosis and knocking down PPM1G can inhibit HCC cell growth and invasion. Additionally, PPM1G interacts with proteins related to alternative splicing and its overexpression alters alternative splicing patterns of genes in HCC cells.

CELL DEATH & DISEASE (2021)

Article Pharmacology & Pharmacy

Atractylodin Attenuates Dextran Sulfate Sodium-Induced Colitis by Alleviating Gut Microbiota Dysbiosis and Inhibiting Inflammatory Response Through the MAPK Pathway

Linghang Qu et al.

Summary: This study demonstrated that atractylodin has the potential to treat ulcerative colitis by inhibiting the MAPK pathway, protecting the intestinal barrier, and improving intestinal microecology.

FRONTIERS IN PHARMACOLOGY (2021)

Article Oncology

The Oncogenic Role of APC/C Activator Protein Cdc20 by an Integrated Pan-Cancer Analysis in Human Tumors

Fei Wu et al.

Summary: The expression levels of CDC20 gene were significantly elevated in various types of cancers and positively correlated with clinical stages in multiple cancer types. High expression of CDC20 was associated with poor prognosis in 10 cancer types in the TCGA dataset.

FRONTIERS IN ONCOLOGY (2021)

Article Cell Biology

TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis

Bonnie Hei Man Liu et al.

Summary: The study revealed that Rab20 is the most frequently downregulated Rab protein in HCC, and restoring Rab20 in metastatic cancer cells results in the release of EVs with reduced activity to promote cell growth, motility, and metastasis. Conversely, EVs released from normal liver cells with Rab20 knockdown lose their suppressive effect on HCC cell growth and motility. Furthermore, the study demonstrated a mechanistic link between tumour cell-derived EVs and glucose metabolism in HCC with Rab20 deregulation through the modulation of glycolytic enzyme TPI1 levels in EVs.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

Article Biochemistry & Molecular Biology

Diosmetin inhibits cell growth and proliferation by regulating the cell cycle and lipid metabolism pathway in hepatocellular carcinoma

Lianhong Pan et al.

Summary: The newly discovered natural flavonoid diosmetin (DSM) has shown promising anti-hepatocellular carcinoma (HCC) properties by inhibiting cell proliferation and interfering with lipid metabolism in HCC cells.

FOOD & FUNCTION (2021)

Article Medicine, Research & Experimental

Fatty acid synthase is a prognostic marker and associated with immune infiltrating in gastric cancers precision medicine

Yangying Zhou et al.

BIOMARKERS IN MEDICINE (2020)

Review Nutrition & Dietetics

Dietary restriction of amino acids for Cancer therapy

Jian-Sheng Kang

NUTRITION & METABOLISM (2020)

Article Gastroenterology & Hepatology

Proteomics analysis identified TPI1 as a novel biomarker for predicting recurrence of intrahepatic cholangiocarcinoma

Wen-Long Yu et al.

JOURNAL OF GASTROENTEROLOGY (2020)

Review Biochemistry & Molecular Biology

The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects

Weiwei Tang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Oncology

The rationale of indoleamine 2,3-dioxygenase inhibition for cancer therapy

Lieve Brochez et al.

EUROPEAN JOURNAL OF CANCER (2017)

Review Cell Biology

Bax and Bak Pores: Are We Closing the Circle?

Katia Cosentino et al.

TRENDS IN CELL BIOLOGY (2017)

Review Immunology

Metabolic Hallmarks of Tumor and immune Cells in the Tumor Microenvironment

Kathrin Renner et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Biochemistry & Molecular Biology

Triosephosphate isomerase 1 suppresses growth, migration and invasion of hepatocellular carcinoma cells

Hao Jiang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Oncology

Glycone-rich Soy Isoflavone Extracts Promote Estrogen Receptor Positive Breast Cancer Cell Growth

Kailee A. Johnson et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2016)

Review Nutrition & Dietetics

Dietary Natural Products for Prevention and Treatment of Liver Cancer

Yue Zhou et al.

NUTRIENTS (2016)

Article Immunology

Baicalein inhibits hepatocellular carcinoma cells through suppressing the expression of CD24

Zhengquan Han et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2015)

Article Oncology

Suppressive effects of dietary genistin and daidzin on rat prostate carcinogenesis

K Kato et al.

JAPANESE JOURNAL OF CANCER RESEARCH (2000)