期刊
BIOCONJUGATE CHEMISTRY
卷 33, 期 2, 页码 353-362出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.1c00595
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资金
- Natural Science Foundation of China [91753201, 21721005]
Natural modified bases in RNA play a crucial role in basic biological processes, and artificial RNA modifications have been widely used for studying RNA interference, structure, and dynamics. This study presents a chemical method for the synthesis of RNA containing C-6 modified purine, which provides a convenient approach for synthesizing oligonucleotides with specific structures.
Natural modified bases in RNA were found to be indispensable for basic biological processes. In addition, artificial RNA modifications have been a versatile toolbox for the study of RNA interference, structure, and dynamics. Here, we present a chemical method for the facile synthesis of RNA containing C-6-modified purine. 6-Iodopurine, as a postsynthetic building block with high reactivity, was used for metal-free construction of C-N, C-O, and C-S bonds under mild conditions and C-C bond formation by Suzuki-Miyaura cross-coupling. Our strategy provides a convenient approach for the synthesis of various RNA modifications, especially for oligonucleotides containing specific structures.
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