Preface to the Special Issue of the European Calcium Society in honor of Professor Sir Michael J. Berridge Preface

Article Biochemistry & Molecular Biology

Adventures with Mike

Robin Irvine

Summary: The text shares some personal memories from a significant adventure I had with Mike.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Keeping zombies alive: The ER-mitochondria Ca2+ transfer in cellular senescence

Ulises Ahumada-Castro et al.

Summary: Cellular senescence results in a permanent cell cycle arrest with apoptosis resistance and a pro-inflammatory phenotype. While senescent cells can promote tissue remodeling in development and after injury, accumulation of these cells during aging or cellular stress can lead to functional decline and contribute to diseases. Understanding the link between mitochondrial metabolism and senescence, particularly in the context of calcium transfer from the endoplasmic reticulum to mitochondria, is crucial for identifying new therapeutic targets to combat senescent cell-related diseases.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Plasma membrane wound repair is characterized by extensive membrane lipid and protein rearrangements in vascular endothelial cells

Arsila P. K. Ashraf et al.

Summary: This study investigated the membrane resealing process in endothelial cells under mechanical stress and found that Ca2+-dependent annexin-phospholipid interactions are crucial for efficient membrane wound repair in endothelial cells.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

The first junior European Calcium Society meeting: calcium research across scales, Kingdoms and countries

Bjorn-Philipp Diercks et al.

Summary: The first junior European Calcium Society online meeting aimed to promote junior researchers in the Ca2+ community by showcasing the diversity of Ca2+ physiology through research across scales and Kingdoms. The meeting featured four scientific sessions covering Ca2+ research from molecular detail to whole organisms, actively involving early-career researchers from different career stages and countries.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Review Cell Biology

Balancing ER-Mitochondrial Ca2+Fluxes in Health and Disease

Jens Loncke et al.

Summary: Organelles cooperate through membrane contact sites to regulate cellular homeostasis and function. Particularly, the communication between the endoplasmic reticulum and mitochondria enables efficient transmission of Ca2+ signals, tightly controlling mitochondrial functions at a microdomain level.

TRENDS IN CELL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Cav1 channels is also a story of non excitable cells: Application to calcium signalling in two different non related models

Lucette Pelletier et al.

Summary: The article discusses similar pathways involving voltage-activated Ca(v)1 channels in two unrelated non-excitable cells: ectoderm cells undergoing neural development and effector Th2 lymphocytes responsible for parasite elimination and allergic diseases. It examines how these channels operate, how they are regulated, and their consequences in terms of gene transcription. The article also considers unresolved questions and potential challenges for the future.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Interaction of G protein-coupled receptor kinases and recoverin isoforms is determined by localization in zebrafish photoreceptors

Nicole Ahrens et al.

Summary: The study revealed diverse properties of recoverin and opsin kinase in zebrafish retina due to differential expression and interaction profiles, indicating distinct roles of different recoverin paralogs in rod and cone cells.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

The IP3 receptor and Ca2+ signaling in trypanosomes

Roberto Docampo et al.

Summary: Trypanosoma cruzi and the T. brucei group of parasites are neglected diseases affecting millions of people globally. These microorganisms have complex life cycles involving insect vectors and mammalian hosts, and possess unique signaling pathways and receptor adaptations that differentiate them from their mammalian counterparts.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Organellar calcium signaling in plants: An update

Niloufar Pirayesh et al.

Summary: Calcium ion plays a crucial role in signaling transduction and stress tolerance in plants. The recognition of organellar calcium signaling has provided new insights into the regulatory functions of Ca2+ in various cellular compartments.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Differential Ca2+ responses and store operated Ca2+ entry in primary cells from human brain tumors

Elena Hernando-Perez et al.

Summary: Brain tumors consist of a variety of tumor types with different levels of malignancy. The study found that malignant tumor cells exhibit calcium responses to ATP and have significantly increased store-operated Ca2+ entry. Furthermore, high grade gliomas have larger SOCE compared to low grade gliomas, suggesting a correlation between SOCE and glioma progression.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Biographical-Item Biochemistry & Molecular Biology

Obituary for Annette Draeger

Volker Gerke et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

2-Methoxyestradiol and its derivatives inhibit store-operated Ca2+ entry in T cells: Identification of a new and potent inhibitor

Anke Loehndorf et al.

Summary: Research has shown that inhibition of SOCE by 2-methoxyestradiol and its derivative STX564 can effectively suppress T cell activation and proliferation by interfering with the Ca2+ entry pathway, potentially serving as a new tool for biological studies.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

In vivo brain imaging of mitochondrial Ca2+ in neurodegenerative diseases with multiphoton microscopy

Maria Calvo-Rodriguez et al.

Summary: Mitochondria play crucial roles in neuronal function, with Ca2+ handling being essential for energy production and cellular fate. Dysfunction in mitochondrial Ca2+ handling has been linked to various neurodegenerative diseases. Investigating mitochondrial Ca2+ dynamics is vital for understanding the role of intracellular Ca2+ signals in physiology and pathology.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Biographical-Item Biochemistry & Molecular Biology

In memoriam David MacLennan (1937-2020)

Marek Michalak

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

The role of Bcl-2 proteins in modulating neuronal Ca2+ signaling in health and in Alzheimer's disease

Manon Callens et al.

Summary: The Bcl-2 protein family plays crucial roles in cellular health and neuronal function, with involvement in regulating apoptosis and Ca2+ signaling. Dysregulation of Bcl-2 proteins may contribute to the progression of neurodegenerative diseases like Alzheimer's, suggesting a potential therapeutic target in the treatment of AD.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Transient receptor potential channel regulation by growth factors

Charlotte Van den Eynde et al.

Summary: Calcium ions play a critical role in cell function, with transient receptor potential (TRP) channels serving as a type of ion channel that can convey various stimuli and potentially participate in cellular responses to changing environments.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Biographical-Item Biochemistry & Molecular Biology

A tribute to Professor Sir Michael J. Berridge FRS (1938-2020)

Martin D. Bootman et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Editorial Material Biochemistry & Molecular Biology

Teaming with NAADP

Sandip Patel et al.

Summary: NAADP is a potent Ca2+-mobilizing messenger with widespread effects in the natural world. Researchers discussed and studied the mechanisms of action of NAADP during a virtual symposium on February 18, 2021.

SCIENCE SIGNALING (2021)

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Article Biochemistry & Molecular Biology

HN1L/JPT2: A signaling protein that connects NAADP generation to Ca2+ microdomain formation

Hannes G. Roggenkamp et al.

Summary: This study identified a new NAADP-binding protein, HN1L/JPT2, which connects NAADP formation with the activation of RYR channels, facilitating Ca2+ release. This protein plays a crucial role in the earliest phase of T cell activation.

SCIENCE SIGNALING (2021)

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Article Biochemistry & Molecular Biology

Ca2+-regulated mitochondrial carriers of ATP-Mg2+/Pi: Evolutionary insights in protozoans

Silvia Garcia-Catalan et al.

Summary: Research has found two variants of ATP-Mg2+/Pi carriers in unicellular eukaryotes, with a common origin unrelated to ADP/ATP translocases, suggesting recurrent losses of the regulatory module in different phyla. These truncated variants of SCaMC are predominantly found in parasitic protists and green algae, indicating a potential relationship with specific lifestyles. Additionally, these variants exhibit intricate structural diversity that may be associated with their pathogenicity.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Choreographing endo-lysosomal Ca2+ throughout the life of a phagosome

Anthony J. Morgan et al.

Summary: Endo-lysosomes, as ubiquitous Ca2+ stores, play a crucial role in a growing number of processes across various cell types. Studying phagocytosis can provide insights into how endo-lysosomal Ca2+ signals are integrated into biological processes and how they can be influenced by disease or infection.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

ORAI3 silencing alters cell proliferation and promotes mitotic catastrophe and apoptosis in pancreatic adenocarcinoma

Charlotte Dubois et al.

Summary: Changes in cytosolic free Ca2+ concentration play a central role in cellular processes. ORAI3 channels are expressed in both normal and pancreatic ductal adenocarcinoma cell lines, affecting store-operated calcium entry (SOCE). Silencing ORAI3 increases SOCE in PDAC cell lines and decreases SOCE in normal pancreatic cell line, impacting proliferation, cell cycle, viability, mitotic catastrophe, and cell death.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

A comprehensive overview of the complex world of the endo- and sarcoplasmic reticulum Ca2+-leak channels

Fernanda O. Lemos et al.

Summary: The endoplasmic reticulum (ER) serves as the main Ca2+ store in cells, actively pumping and releasing Ca2+ through SERCA pumps, IP3 receptors, and ryanodine receptors. The function and impact of Ca2+ leakage channels are a major focus of research in this field.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article Cell Biology