期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1869, 期 6, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbamcr.2022.119223
关键词
Post-translational modifications; Regulatory T cells; T helper type 17 cells; Inflammatory diseases
资金
- National Science Centre of Poland Sheng1 [2018/30/Q/NZ6/00769]
- Academy of Finland [325965]
- Academy of Finland (AKA) [325965, 325965] Funding Source: Academy of Finland (AKA)
Regulatory T (Treg) cells and Th17 cells play essential roles in immune homeostasis and infection. Dysregulation of the Th17/Treg cell balance contributes to the development of various diseases. Multiple factors influence the balance, including signaling, cytokines, metabolism, and epigenetic regulators.
Regulatory T (Treg) cells and Th17 cells are subsets of CD4(+) T cells which play an essential role in immune homeostasis and infection. Dysregulation of the Th17/Treg cell balance was shown to be implicated in the development and progression of several disorders such as autoimmune disease, inflammatory disease, and cancer. Multiple factors, including T cell receptor (TCR) signals, cytokines, metabolic and epigenetic regulators can influence the differentiation of Th17 and Treg cells and affect their balance. Accumulating evidence indicates that the activity of key molecules such as forkhead box P3 (Foxp3), the retinoic acid-related orphan receptor gamma t (ROR gamma t), and signal transducer and activator of transcription (STAT)s are modulated by the number of post-translational modifications (PTMs) such as phosphorylation, methylation, nitrosylation, acetylation, glycosylation, lipidation, ubiquitination, and SUMOylation. PTMs might affect the protein folding efficiency and protein conformational stability, and consequently determine protein structure, localization, and function. Here, we review the recent progress in our understanding of how PTMs modify the key molecules involved in the Th17/Treg cell differentiation, regulate the Th17/Treg balance, and initiate autoimmune diseases caused by dysregulation of the Th17/Treg balance. A better understanding of Th17/Treg regulation may help to develop novel potential therapeutics to treat immune-related diseases.
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