期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1869, 期 2, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbamcr.2021.119170
关键词
Myogenesis; Cell adhesion molecules; Satellite cells
资金
- Townsville Hospital and Health Service (THHS) Study Education and Research Trust Account (SERTA) [2021-14]
- James Cook University Sandpit
- James Cook University PhD Scholarship
Skeletal muscles are responsible for voluntary body movements and undergo a complex process of myogenesis for formation, maintenance, regeneration, and repair. This process involves satellite cells, transcription factors, cell adhesion molecules, and signaling cascades for effective muscle growth and function.
Skeletal muscles represent a complex and highly organised tissue responsible for all voluntary body movements. Developed through an intricate and tightly controlled process known as myogenesis, muscles form early in development and are maintained throughout life. Due to the constant stresses that muscles are subjected to, skeletal muscles maintain a complex course of regeneration to both replace and repair damaged myofibers and to form new functional myofibers. This process, made possible by a pool of resident muscle stem cells, termed satellite cells, and controlled by an array of transcription factors, is additionally reliant on a diverse range of cell adhesion molecules and the numerous signaling cascades that they initiate. This article will review the literature surrounding adhesion molecules and their roles in skeletal muscle myogenesis and repair.
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