期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1864, 期 1, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbamem.2021.183795
关键词
Orthodox aquaporins; Aquaglyceroporins; Perilipin 1; Human adipocytes; AQP
资金
- China Scholarship Council (CSC) [201706170065]
- Swedish Research Council [2016-01319, 201705816]
- Diabetesfonden [DIA2020-500]
- Swedish Research Council [2016-01319] Funding Source: Swedish Research Council
Aquaporins play a crucial role in maintaining water homeostasis in the human body, and recent studies have shown the physiological importance of aquaporins as glycerol channels. In addition to aquaglyceroporins, the discovery of AQP1 in human primary adipocytes suggests a role in response to hyperosmotic stress. The coordination of aquaglyceroporins and perilipin 1 in human adipocytes contributes to the homeostasis of glycerol and water during fasting and feeding.
Aquaporins play a crucial role in water homeostasis in the human body, and recently the physiological importance of aquaporins as glycerol channels have been demonstrated. The aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) represent key glycerol channels, enabling glycerol flux across the membranes of cells. Adipocytes are the major source of glycerol and during lipolysis, glycerol is released to be metabolized by other tissues through a well-orchestrated process. Here we show that both AQP3 and AQP7 bind to the lipid droplet protein perilipin 1 (PLIN1), suggesting that PLIN1 is involved in the coordination of the subcellular translocation of aquaglyceroporins in human adipocytes. Moreover, in addition to aquaglyceroporins, we discovered by transcriptome sequencing that AQP1 is expressed in human primary adipocytes. AQP1 is mainly a water channel and thus is thought to be involved in the response to hyper-osmotic stress by efflux of water during hyperglycemia. Thus, this data suggests a contribution of both orthodox aquaporin and aquaglyceroporin in human adipocytes to maintain the homeostasis of glycerol and water during fasting and feeding.
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