4.7 Review

Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP)

Joseph D. Ho et al.

Summary: The research focused on inhibiting the formation of both PGs and LTs by generating ligand-protein X-ray crystal structures and using molecular modeling and structure-based drug design (SBDD) to identify hybrid structures. Compounds 4 and 5 were synthesized and showed potent in vitro inhibition of both targets, offering insights into potential dual inhibitors for these important integral membrane protein drug targets.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2021)

Article Pharmacology & Pharmacy

Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators

Simona Pace et al.

Summary: CS effectively inhibits human 5-lipoxygenase activity, suppresses the formation of leukotrienes, promotes the generation of lipid mediators produced by 12-/15-lipoxygenases, and switches from leukotriene biosynthesis to specialized pro-resolving mediator formation, potentially serving as a pharmacological strategy for intervention in inflammatory disorders.

PHARMACOLOGICAL RESEARCH (2021)

Article Allergy

A Boxed Warning for Montelukast: The FDA Perspective

Katherine Clarridge et al.

Summary: The FDA identified neuropsychiatric adverse events with Singulair use in 2007 and conducted multiple reviews and studies to address stakeholders' concerns, resulting in labeling updates to restrict use for allergic rhinitis indication. The asthma indication remained unchanged following benefit-risk considerations.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

Article Multidisciplinary Sciences

Structural insights on ligand recognition at the human leukotriene B4 receptor 1

Nairie Michaelian et al.

Summary: The leukotriene B4 receptor 1 (BLT1) plays a role in various human diseases and the crystal structure study reveals molecular determinants of ligand binding and selectivity toward different receptor subtypes, providing insights for future structure-based drug design.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products

Nathaniel C. Gilbert et al.

NATURE CHEMICAL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases

Adam R. Offenbacher et al.

MOLECULES (2020)

Review Biochemistry & Molecular Biology

Specialized pro-resolving mediator network: an update on production and actions

Nan Chiang et al.

LIPID MEDIATORS (2020)

Review Biochemistry & Molecular Biology

Emerging structural biology of lipid G protein-coupled receptors

Martin Audet et al.

PROTEIN SCIENCE (2019)

Article Multidisciplinary Sciences

Structural basis of ligand recognition at the human MT1 melatonin receptor

Benjamin Stauch et al.

NATURE (2019)

Article Pharmacology & Pharmacy

Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator Biosynthesis

Jana Gerstmeieri et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Multidisciplinary Sciences

Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs

Aleksandra Luginina et al.

SCIENCE ADVANCES (2019)

Article Biochemistry & Molecular Biology

The MemProtMD database: a resource for membrane-embedded protein structures and their lipid interactions

Thomas D. Newport et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Multidisciplinary Sciences

Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors

Anastasiia Gusach et al.

NATURE COMMUNICATIONS (2019)

Review Medicine, Research & Experimental

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

Charles N. Serhan et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Biochemistry & Molecular Biology

Na+-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1

Tetsuya Hori et al.

NATURE CHEMICAL BIOLOGY (2018)

Article Biotechnology & Applied Microbiology

A comprehensive map of molecular drug targets

Rita Santos et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Review Immunology

Recent advances in clinical development of leukotriene B4 pathway drugs

L. Bhatt et al.

SEMINARS IN IMMUNOLOGY (2017)

Article Biochemistry & Molecular Biology

Identification of the Substrate Access Portal of 5-Lipoxygenase

Sunayana Mitra et al.

BIOCHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein

Christoph Lehmann et al.

FASEB JOURNAL (2015)

Review Biochemistry & Molecular Biology

The structural basis for specificity in lipoxygenase catalysis

Marcia E. Newcomer et al.

PROTEIN SCIENCE (2015)

Article Biochemistry & Molecular Biology

Inhibition of 5-Lipoxygenase Selectively Triggers Disruption of c-Myc Signaling in Prostate Cancer Cells

Sivalokanathan Sarveswaran et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Pharmacology & Pharmacy

Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthases

Thea K. Kleinschmidt et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)

Article Cell Biology

Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue

Romain A. Colas et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2014)

Article Biochemistry & Molecular Biology

The Structure of Human 15-Lipoxygenase-2 with a Substrate Mimic

Matthew J. Kobe et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Crystal Structure of a Lipoxygenase in Complex with Substrate THE ARACHIDONIC ACID-BINDING SITE OF 8R-LIPOXYGENASE

David B. Neau et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Multidisciplinary Sciences

Pro-resolving lipid mediators are leads for resolution physiology

Charles N. Serhan

NATURE (2014)

Article Multidisciplinary Sciences

Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis

Devaraj Basavarajappa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway

Gabrielle Fredman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Biochemistry & Molecular Biology

Allosteric sodium in class A GPCR signaling

Vsevolod Katritch et al.

TRENDS IN BIOCHEMICAL SCIENCES (2014)

Article Biochemistry & Molecular Biology

Structure and interaction with phospholipids of a prokaryotic lipoxygenase from Pseudomonas aeruginosa

Albert Garreta et al.

FASEB JOURNAL (2013)

Article Neurosciences

Modulation of 5-Lipoxygenase in Proteotoxicity and Alzheimer's Disease

Elvira Valera et al.

JOURNAL OF NEUROSCIENCE (2013)

Article Biochemistry & Molecular Biology

Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-κB in hepatoma cells

Yu Zhao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Article Biochemistry & Molecular Biology

OPM database and PPM web server: resources for positioning of proteins in membranes

Mikhail A. Lomize et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Multidisciplinary Sciences

The Structure of Human 5-Lipoxygenase

Nathaniel C. Gilbert et al.

SCIENCE (2011)

Article Cell Biology

Leukotriene Inflammatory Mediators Meet Their Match

Colin D. Funk

SCIENCE TRANSLATIONAL MEDICINE (2011)

Article Biochemistry & Molecular Biology

Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102

Julia Esser et al.

BIOCHEMICAL JOURNAL (2010)

Review Cardiac & Cardiovascular Systems

The 5-lipoxygenase/leukotriene pathway in preclinical models of cardiovascular disease

Daniel Poeckel et al.

CARDIOVASCULAR RESEARCH (2010)

Article Pharmacology & Pharmacy

Oxymetazoline Inhibits and Resolves Inflammatory Reactions in Human Neutrophils

Ingrid Beck-Speier et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2009)

Article Immunology

12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2

Toshiaki Okuno et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

Article Multidisciplinary Sciences

The nuclear membrane organization of leukotriene synthesis

Asim K. Mandal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase

Daniel Martinez Molina et al.

NATURE (2007)

Article Multidisciplinary Sciences

Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein

Andrew D. Ferguson et al.

SCIENCE (2007)

Review Biophysics

The role of hydrophobic interactions in positioning of peripheral proteins in membranes

Andrei L. Lomize et al.

BMC STRUCTURAL BIOLOGY (2007)

Review Biochemistry & Molecular Biology

Control of oxygenation in lipoxygenase and cyclooxygenase catalysis

Claus Schneider et al.

CHEMISTRY & BIOLOGY (2007)

Article Multidisciplinary Sciences

Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production

Marija Rakonjac et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Immunology

Neutrophil-derived leukotriene B4 is required for infl ammatory arthritis

M Chen et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

Article Biochemistry & Molecular Biology

Phosphorylation-independent β-arrestin translocation and internalization of leukotriene B4 receptors

VR Jala et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Biochemistry & Molecular Biology

Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution

CN Serhan

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2005)

Article Multidisciplinary Sciences

The membrane organization of leukotriene synthesis

AK Mandal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

A single active site residue directs oxygenation stereospecificity in lipoxygenases: Stereocontrol is linked to the position of oxygenation

G Coffa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

Lipoxygenase genes and their targeted disruption

CD Funk et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2002)

Article Biochemistry & Molecular Biology

Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase

S Kulkarni et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

5-Lipoxygenase interacts with coactosin-like protein

P Provost et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2

T Yokomizo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity

T Hammarberg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)