期刊
BIOCHEMICAL JOURNAL
卷 478, 期 20, 页码 3723-3739出版社
PORTLAND PRESS LTD
DOI: 10.1042/BCJ20210071
关键词
-
资金
- Fration Francaise de Recherche sur le Diabete
Sterol Regulatory Element Binding Protein-1c is a transcription factor that controls lipid synthesis in the liver from glucose, playing a crucial role in energy storage. Discovered in the early nineties, it has been the subject of over 5000 studies to understand its activation mechanism and physiological and pathological roles.
Sterol Regulatory Element Binding Protein-1c is a transcription factor that controls the synthesis of lipids from glucose in the liver, a process which is of utmost importance for the storage of energy. Discovered in the early nineties by B. Spiegelman and by M. Brown and J. Goldstein, it has generated more than 5000 studies in order to elucidate its mechanism of activation and its role in physiology and pathology. Synthetized as a precursor found in the membranes of the endoplasmic reticulum, it has to be exported to the Golgi and cleaved by a mechanism called regulated intramembrane proteolysis. We reviewed in 2002 its main characteristics, its activation process and its role in the regula-tion of hepatic glycolytic and lipogenic genes. We particularly emphasized that Sterol Regulatory Element Binding Protein-1c is the mediator of insulin effects on these genes. In the present review, we would like to update these informations and focus on the response to insulin and to another actor in Sterol Regulatory Element Binding Protein-1c activation, the endoplasmic reticulum stress.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据