期刊
BIOCHEMICAL GENETICS
卷 60, 期 3, 页码 843-867出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10528-021-10138-8
关键词
lncRNAs; NEAT1; Cancer; Noncancerous
资金
- National Natural Science Foundation of China [81871835]
- Shanghai Frontiers Science Research Base of Exercise and Metabolic Health and Shanghai Key Laboratory for Human Athletic Ability Development and Support (Shanghai University of Sport) [11DZ2261100]
NEAT1, a long non-coding RNA highly expressed in various organs, is involved in paraspeckle formation and gene expression, making it a potential biomarker for treating diseases. Despite its potential, the mechanisms and downstream effects of abnormal NEAT1 expression in diseases remain unclear.
Nuclear enriched abundant transcript 1 (NEAT1), consisting of two kinds of lncRNAs of 3.7 kB NEAT1-1 and 23 kB NEAT1-2, can be highly expressed in organs and tissues such as the ovary, prostate, colon, and pancreas, and is involved in paraspeckle formation and mRNA editing and gene expression. Therefore, NEAT1 is a potential biomarker for the treatment of a variety of diseases, which may be caused by two factors (isoforms of NEAT1 and NEAT1 sponging miRNA as ceRNA). However, there is still much confusion about the mechanism and downstream effector between the abnormal expression of NEAT1 and various diseases. This review summarizes recent research progress on NEAT1 in cancer and other pathologies and provides a more reliable theoretical basis for the treatment of related diseases.
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