期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 583, 期 -, 页码 22-28出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2021.10.057
关键词
Chlorogenic acid; Dermal protein matrix; Epidermal skin barrier; Collagen; Skin barrier genes
资金
- National Research Foundation of Korea (NRF) - Korea govern-ment (MSIT) [2021R1F1A1062392]
- National Research Foundation of Korea [2021R1F1A1062392] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Chlorogenic acid is a polyphenol found in human diet that impacts human cells, promoting procollagen type I production and skin barrier gene expression. It can be used to restore impaired dermal matrix network and epidermal skin barrier.
Chlorogenic acid is one of the most abundant polyphenols found in human diet. It is well-documented that chlorogenic acid has a significant impact on human cells, especially in the regulation of inflammation and metabolic processes. However, its role in regulating skin functions, especially with respect to the dermal collagen network or epidermal skin barrier, has not yet been elucidated. Here, we report that chlorogenic acid treatment can induce production of procollagen type I in human dermal fibroblast, Hs68 cell lines. Moreover, this treatment can stimulate upregulation of skin barrier genes, including the ones encoding filaggrin (FLG), involucrin (IVL), and envoplakin (EVPL), in epidermal keratinocytes. Chlorogenic acid also triggered a multifaceted response in the cytokine profile of keratinocytes. Therefore, we suggest that chlorogenic acid can be used to restore the impaired dermal matrix network as well as the epidermal skin barrier. (c) 2021 Elsevier Inc. All rights reserved.
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